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<StructureSection load='1mvp' size='340' side='right'caption='[[1mvp]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1mvp' size='340' side='right'caption='[[1mvp]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1mvp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Avima Avima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVP FirstGlance]. <br>
<table><tr><td colspan='2'>[[1mvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_myeloblastosis-associated_virus Avian myeloblastosis-associated virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVP FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvp OCA], [http://pdbe.org/1mvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mvp RCSB], [http://www.ebi.ac.uk/pdbsum/1mvp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvp ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvp OCA], [https://pdbe.org/1mvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvp RCSB], [https://www.ebi.ac.uk/pdbsum/1mvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GAG_AVIMA GAG_AVIMA]] Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor.  
[https://www.uniprot.org/uniprot/GAG_AVIMA GAG_AVIMA] Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mvp ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mvp ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the retroviral proteinase from avian myeloblastosis associated virus (MAV) has been determined and refined at 2.2 A resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase-inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases.
Structural studies of the retroviral proteinase from avian myeloblastosis associated virus.,Ohlendorf DH, Foundling SI, Wendoloski JJ, Sedlacek J, Strop P, Salemme FR Proteins. 1992 Nov;14(3):382-91. PMID:1332025<ref>PMID:1332025</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1mvp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Avima]]
[[Category: Avian myeloblastosis-associated virus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Foundling, S I]]
[[Category: Foundling SI]]
[[Category: Ohlendorf, D H]]
[[Category: Ohlendorf DH]]
[[Category: Salemme, F R]]
[[Category: Salemme FR]]

Latest revision as of 10:49, 14 February 2024

STRUCTURAL STUDIES OF THE RETROVIRAL PROTEINASE FROM AVIAN MYELOBLASTOSIS ASSOCIATED VIRUSSTRUCTURAL STUDIES OF THE RETROVIRAL PROTEINASE FROM AVIAN MYELOBLASTOSIS ASSOCIATED VIRUS

Structural highlights

1mvp is a 2 chain structure with sequence from Avian myeloblastosis-associated virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GAG_AVIMA Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1mvp, resolution 2.20Å

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