1mv3: Difference between revisions

<StructureSection load='1mv3' size='340' side='right'caption='[[1mv3]]' scene=''>

<table><tr><td colspan='2'>[[1mv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MV3 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mv3 OCA], [https://pdbe.org/1mv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1mv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mv3 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[https://omim.org/entry/255200 255200]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>  

[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

[[Category: Homo sapiens]]

[[Category: Arrowsmith CH]]

[[Category: Pineda-Lucena A]]