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| == PGK in the Glycolysis Cycle == | | == PGK in the Glycolysis Cycle == |
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| '''Phosphoglycerate kinase''' is a crucial enzyme in the glycolysis cycle. This cycle is a series of ten reactions which ultimately breaks down glucose into pyruvate while generating 2 NADH and 2 ATP molecules. Phosphoglycerate kinase is the seventh enzyme in the cycle which catalyzes the reaction of 1,3-Biphosphoglycerate and ADP to produce <scene name='Shane_Harmon_Sandbox/Product/2'>3-Phosphoglycerate</scene> and <scene name='Shane_Harmon_Sandbox/Atp/4'>ATP</scene>. This method for ATP production is known as substrate-level phosphorylation because it produces energy storing ATP molecules without the use of oxygen, NADH, or an ATPase. The reaction is highly exergonic allowing it to be coupled with the less thermodynamically favored GADPH reaction of the cycle so both reactions occur spontaneously. See [[Glycolysis Enzymes]]. | | '''Phosphoglycerate kinase''' is a crucial enzyme in the glycolysis cycle. This cycle is a series of ten reactions which ultimately breaks down glucose into pyruvate while generating 2 NADH and 2 ATP molecules. Phosphoglycerate kinase is the seventh enzyme in the cycle which catalyzes the reaction of 1,3-Biphosphoglycerate and ADP to produce <scene name='Shane_Harmon_Sandbox/Product/2'>3-Phosphoglycerate</scene> and <scene name='Shane_Harmon_Sandbox/Atp/4'>ATP</scene>. This method for ATP production is known as substrate-level phosphorylation because it produces energy storing ATP molecules without the use of oxygen, NADH, or an ATPase. The reaction is highly exergonic allowing it to be coupled with the less thermodynamically favored GADPH reaction of the cycle so both reactions occur spontaneously. See [[Glycolysis Enzymes]], [[Gluconeogenesis]]. |
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| == Structure == | | == Structure == |
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| </StructureSection> | | </StructureSection> |
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| ==3D structures of phosphoglycerate kinase ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *'''Phosphoglycerate kinase'''
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| **[[2pgk]] – PGK – horse<br />
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| **[[2p9q]] – mPGK2 – mouse<BR />
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| **[[1fw8]] – yPGK – yeast<BR />
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| **[[3oz7]], [[3oza]] – PfPGK – ''Plasmodium falciparum''<BR />
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| **[[3q3v]] – PGK – ''Campylobacter jejuni''<BR />
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| **[[2ie8]] – PGK – ''Thermus caldophilus''<BR />
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| **[[1zmr]] – PGK – ''Escherichia coli''<BR />
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| **[[1v6s]] – PGK – ''Thermos thermophilus''<BR />
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| **[[3uwd]] - PGK – ''Bacillus anthracis''<br />
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| **[[4dg5]] – PGK – ''Staphylococcus aureus''<br />
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| **[[4ehj]] – FtPGK – ''Francisella tularensis''<br />
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| **[[5bt8]] – PGK – ''Acinetobacter baumannii''<br />
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| **[[6i06]] – PsPGK – ''Pseudomonas''<br />
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| *Phosphoglycerate kinase binary complex
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| **[[2xe6]], [[3c39]] – hPGK1 + PGA - human<BR />
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| **[[2zgv]] - hPGK1 + ADP<BR />
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| **[[5o7d]], [[5mxm]], [[5m6z]], [[5m3u]], [[5m1r]] – hPGK1 (mutant) + ADP <br />
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| **[[5np8]] – hPGK1 + inhibitor <br />
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| **[[3c3b]], [[3c3c]] - hPGK1 + CDP <br />
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| **[[3zoz]] – hPGK1 + Br<br />**[[1vjc]] – pPGK + MgATP – pig<BR />
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| **[[1vjd]] - pPGK + ATP<BR />
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| **[[2p9t]] – mPGK2 + PGA<BR />
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| **[[1ltk]] – PfPGK + AMP<BR />
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| **[[16pk]]– TbPGK (mutant) + bisubstrate analog – ''Trypanosoma brucei''<BR />
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| **[[1php]] – PGK + ADP – ''Geobacillus stearothermophilus''<BR />
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| **[[4fey]] – FtPGK + ADP<br />
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| **[[1vpe]] – PGK + ANP – ''Thermotoga maritima''<BR />
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| **[[2cun]] – PGK + PGA – ''Pyrococcus horikoshii''<BR />
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| **[[3zlb]] - PGK + ANP – ''Streptococcus pneumoniae''<br />
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| **[[4ng4]] – PGK + ADP – ''Coxiella burnetii''<br />
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| **[[6hxe]] – PsPGK + 3PG <br />
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| *Phosphoglycerate kinase ternary complex
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| **[[2paa]] - mPGK2 + ATP + PGA<BR />
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| **[[1hdi]] - mPGK + MgATP + PGA<BR />
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| **[[1kf0]] - mPGK + AMPPCP + PGA<BR />
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| **[[1qpg]] - yPGK + MgATP + PGA<BR />
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| **[[3pgk]] - yPGK + ATP + PGA<BR />
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| **[[13pk]] - TbPGK + ADP + PGA<BR />
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| **[[2y3i]], [[2ybe]], [[2xe7]], [[2x13]], [[3c3a]] – hPGK1 + ADP + PGA <BR />
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| **[[2x15]] - hPGK1 + bisphosphoglycerate + ADP<br />
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| **[[2xe8]] - hPGK1 + AMPPNP + PGA<BR />
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| **[[2x14]] - hPGK1 (mutant) + AMPPCP + PGA<BR />
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| **[[2wzb]] - hPGK1 + ADP + MgF3 + PGA<BR />
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| **[[4axx]] - hPGK1 + ADP + BeF3 + 3PG<br />
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| **[[4o33]] - hPGK1 + terazosin + 3PG<br />
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| **[[2wzc]] - hPGK1 + ADP + AlF4 + PGA<BR />
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| **[[2wzd]] - hPGK1 (mutant) + ADP + AlF3 + PGA<BR />
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| **[[2paa]] - mPGK2 + ATP + PGA<BR />
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| **[[1hdi]] - mPGK + MgATP + PGA<BR />
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| **[[1kf0]] - mPGK + AMPPCP + PGA<BR />
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| **[[4o3f]] - mPGK1 + terazosin + 3PG<br />
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| **[[1qpg]] - yPGK + MgATP + PGA<BR />
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| **[[3pgk]] - yPGK + ATP + PGA<BR />
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| **[[13pk]] - TbPGK + ADP + PGA<BR />
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| }}
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| ==Additional Resources== | | ==Additional Resources== |