1a7y: Difference between revisions
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<StructureSection load='1a7y' size='340' side='right'caption='[[1a7y]], [[Resolution|resolution]] 0.94Å' scene=''> | <StructureSection load='1a7y' size='340' side='right'caption='[[1a7y]], [[Resolution|resolution]] 0.94Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1a7y]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1a7y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A7Y FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.94Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=EEE:ETHYL+ACETATE'>EEE</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=PRD_000001:Actinomycin+D'>PRD_000001</scene>, <scene name='pdbligand=PXZ:2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE'>PXZ</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7y OCA], [https://pdbe.org/1a7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a7y RCSB], [https://www.ebi.ac.uk/pdbsum/1a7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a7y ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Streptomyces antibioticus]] | [[Category: Streptomyces antibioticus]] | ||
[[Category: Bahner | [[Category: Bahner I]] | ||
[[Category: Lackner | [[Category: Lackner H]] | ||
[[Category: Schafer | [[Category: Schafer M]] | ||
[[Category: Sheldrick | [[Category: Sheldrick GM]] | ||
Latest revision as of 10:45, 15 November 2023
CRYSTAL STRUCTURE OF ACTINOMYCIN DCRYSTAL STRUCTURE OF ACTINOMYCIN D
Structural highlights
Publication Abstract from PubMedUntwinned single crystals of the actinomycins D and Z3 that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which are present in the form of a hydrogen-bridged dimer related by a pseudo-twofold axis (see picture). Crystal Structures of Actinomycin D and Actinomycin Z3.,Schafer M, Sheldrick GM, Bahner I, Lackner H Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2381-2384. doi:, 10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L. PMID:29710967[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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