1iv2: Difference between revisions

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<StructureSection load='1iv2' size='340' side='right'caption='[[1iv2]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='1iv2' size='340' side='right'caption='[[1iv2]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1iv2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IV2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1iv2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IV2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDP:CYTIDINE-5-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iv1|1iv1]], [[1iv3|1iv3]], [[1iv4|1iv4]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDP:CYTIDINE-5-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv2 OCA], [https://pdbe.org/1iv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1iv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv2 ProSAT], [https://www.topsan.org/Proteins/RSGI/1iv2 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv2 OCA], [http://pdbe.org/1iv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iv2 RCSB], [http://www.ebi.ac.uk/pdbsum/1iv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv2 ProSAT], [http://www.topsan.org/Proteins/RSGI/1iv2 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ISPF_THET8 ISPF_THET8]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).<ref>PMID:12499535</ref>
[https://www.uniprot.org/uniprot/ISPF_THET8 ISPF_THET8] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).<ref>PMID:12499535</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kishida, H]]
[[Category: Thermus thermophilus]]
[[Category: Kuzuyama, T]]
[[Category: Kishida H]]
[[Category: Park, S Y]]
[[Category: Kuzuyama T]]
[[Category: Structural genomic]]
[[Category: Park S-Y]]
[[Category: Sirouzu, M]]
[[Category: Sirouzu M]]
[[Category: Tame, J R.H]]
[[Category: Tame JRH]]
[[Category: Terada, T]]
[[Category: Terada T]]
[[Category: Unzai, S]]
[[Category: Unzai S]]
[[Category: Wada, T]]
[[Category: Wada T]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Isoprenoid]]
[[Category: Lyase]]
[[Category: Non-mevalonate]]
[[Category: Rsgi]]
[[Category: Synthase]]

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