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==SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2==
==SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2==
<StructureSection load='1duj' size='340' side='right'caption='[[1duj]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1duj' size='340' side='right'caption='[[1duj]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1duj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DUJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1duj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DUJ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1duj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1duj OCA], [http://pdbe.org/1duj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1duj RCSB], [http://www.ebi.ac.uk/pdbsum/1duj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1duj ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1duj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1duj OCA], [https://pdbe.org/1duj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1duj RCSB], [https://www.ebi.ac.uk/pdbsum/1duj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1duj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MD2L1_HUMAN MD2L1_HUMAN]] Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.<ref>PMID:10700282</ref> <ref>PMID:11804586</ref> <ref>PMID:15024386</ref>
[https://www.uniprot.org/uniprot/MD2L1_HUMAN MD2L1_HUMAN] Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.<ref>PMID:10700282</ref> <ref>PMID:11804586</ref> <ref>PMID:15024386</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Coldiron, M]]
[[Category: Coldiron M]]
[[Category: Fang, G]]
[[Category: Fang G]]
[[Category: Lin, Y]]
[[Category: Lin Y]]
[[Category: Luo, X]]
[[Category: Luo X]]
[[Category: Yu, H]]
[[Category: Yu H]]
[[Category: Cell cycle]]
[[Category: Mad2]]
[[Category: Spindle assembly checkpoint]]

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