6ujm: Difference between revisions
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New page: '''Unreleased structure''' The entry 6ujm is ON HOLD Authors: Huang, Q., Cerione, R.A. Description: Crystal structure of human GAC in complex with inhibitor UPGL00013 [[Category: Unrel... |
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==Crystal structure of human GAC in complex with inhibitor UPGL00013== | |||
<StructureSection load='6ujm' size='340' side='right'caption='[[6ujm]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ujm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UJM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q94:N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide'>Q94</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ujm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ujm OCA], [https://pdbe.org/6ujm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ujm RCSB], [https://www.ebi.ac.uk/pdbsum/6ujm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ujm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. | |||
==See Also== | |||
*[[Glutaminase 3D structures|Glutaminase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cerione RA]] | |||
[[Category: Huang Q]] | |||
Latest revision as of 10:52, 11 October 2023
Crystal structure of human GAC in complex with inhibitor UPGL00013Crystal structure of human GAC in complex with inhibitor UPGL00013
Structural highlights
FunctionGLSK_HUMAN Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. See Also |
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