6uj6: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 6uj6 is ON HOLD
+==X-ray Crystal Structure of Chromium-transferrin with Synergistic Anion Malonate==
+<StructureSection load='6uj6' size='340' side='right'caption='[[6uj6]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UJ6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CR:CHROMIUM+ION'>CR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uj6 OCA], [https://pdbe.org/6uj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uj6 RCSB], [https://www.ebi.ac.uk/pdbsum/6uj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uj6 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Transferrin, the Fe(III) transport protein in mammalian blood, has been suggested to also serve as a Cr(III) transporter and as part of a Cr(III) detoxification system; however, the structure of the metal-binding sites has never been fully elucidated with bound Cr(III). Chromium(III)-transferrin was crystallized in the presence of the synergistic anion malonate. In the crystals, the protein exists with a closed C-terminal lobe containing a Cr(III) ion and an open, unoccupied N-terminal lobe. The overall structure and the metal ion environments are extremely similar to those of Fe(III)- and Ti(IV)-containing transferrin crystallized under comparable conditions. The octahedral coordination about the Cr(III) is comprised of four ligands provided by the protein (two tyrosine residues, a histidine residue, and an aspartate residue) and a chelating malonate anion. This represents the first crystal structure of a Cr(III)-containing protein that binds Cr(III) as part of its physiological function.
-Authors:
+X-ray structure of chromium(III)-containing transferrin: First structure of a physiological Cr(III)-binding protein.,Petersen CM, Edwards KC, Gilbert NC, Vincent JB, Thompson MK J Inorg Biochem. 2020 Sep;210:111101. doi: 10.1016/j.jinorgbio.2020.111101. Epub , 2020 May 23. PMID:32650146<ref>PMID:32650146</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6uj6" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Transferrin 3D structures|Transferrin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Edwards KC]]
+[[Category: Gilbert NC]]
+[[Category: Petersen CM]]
+[[Category: Thompson MK]]
+[[Category: Vincent JB]]