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| <StructureSection load='' size='350' side='right' scene='54/542330/Cv/1' caption='Human thymidylate kinase complex with HIV prodrug AZTP, ADP and Mg+2 ion (green)'> | | <StructureSection load='' size='350' side='right' scene='54/542330/Cv/1' caption='Human thymidylate kinase complex with HIV prodrug AZTP, ADP and Mg+2 ion (green)'> |
| | | __TOC__ |
| == Function == | | == Function == |
| '''Thymidylate kinase''' (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis<ref>PMID:23394555</ref>. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. For more details see [[Student Project 8 for UMass Chemistry 423 Spring 2015]]. | | '''Thymidylate kinase''' (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis<ref>PMID:23394555</ref>. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. For more details see [[Student Project 8 for UMass Chemistry 423 Spring 2015]]. |
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| *<scene name='54/542330/Cv/8'>ATM binding site</scene>. | | *<scene name='54/542330/Cv/8'>ATM binding site</scene>. |
| *<scene name='54/542330/Cv/9'>Whole binding site</scene>. | | *<scene name='54/542330/Cv/9'>Whole binding site</scene>. |
| </StructureSection>
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| == 3D Structures of thymidylate kinase == | | == 3D Structures of thymidylate kinase == |
| | [[Thymidylate kinase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Thymidylate kinase
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| **[[2cck]], [[4f4i]] – SaTMK – ''Staphylococcus aureus'' <br />
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| **[[2pbr]], [[4s2e]], [[5h5b]] – AaTMK – ''Aquifex aeolicus'' <br />
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| **[[5xb5]], [[5xbh]] – AaTMK (mutant) <br />
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| **[[2plr]] – TMK – ''Sulfolobus tokodaii'' <br />
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| **[[3ld9]] – TMK – ''Ehrlichia chafeensis''<br />
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| **[[3v9p]] – TMK – ''Burkholderia thailandensis''<br />
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| **[[3uwk]], [[3uwo]] – PaTMK – ''Pseudomonas aeruginosa''<br />
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| *Thymidylate kinase complex with HIV prodrug AZT derivative
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| **[[2tmk]] – yTMK + AZTP <br />
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| **[[4eaq]] – SaTMK + AZTP <br />
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| **[[4gmd]] – PaTMK + AZTP <br />
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| **[[4tmk]], [[5tmp]] – TMK + AZTP – ''Escherichia coli''<br />
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| **[[1w2h]] – MtTMK + AZTP - ''Mycobacterium tuberculosis'' <br />
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| **[[1e98]], [[1e99]], [[1e9d]] – hTMK (mutant) + AZTP + ADP<br />
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| *Thymidylate kinase complex with nucleotides
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| **[[2v54]] – VvTMK + TDP – Vaccinia virus<br />
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| **[[2w0s]] – VvTMK + brivudin-MP <br />
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| **[[1tmk]] – yTMK + dTMP - yeast<br />
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| **[[4e5u]] – PaTMK + dTMP <br />
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| **[[2ccg]], [[2ccj]], [[4dwj]] – SaTMK + dTMP <br />
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| **[[1g3u]], [[1gsi]], [[1n5i]], [[1n5k]] – MtTMK + dTMP <br />
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| **[[1w2g]] – MtTMK + thymidine <br />
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| **[[1gtv]] – MtTMK + TDP <br />
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| **[[1n5j]] – MtTMK + TDP + TTP<br />
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| **[[1n5l]] – MtTMK + TDP + dTMP <br />
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| **[[1mrs]] – MtTMK + UMP derivative <br />
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| **[[3uxm]], [[4esh]] – PaTMK + deoxy thymidine derivative <br />
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| **[[3hjn]] – TMK + ADP + TDP – ''Thermotoga maritima''<br />
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| **[[1e2d]], [[1e2e]], [[1e2f]], [[1e9e]], [[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
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| **[[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
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| **[[4edh]] – PaTMK + ADP + dTMP <br />
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| **[[3lv8]] – VcTMK + ADP + dTMP + TDP – ''Vibrio cholerae''<br />
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| **[[3n2i]] – VcTMK + thymidine + thymidine deoxy-thymidine<br />
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| **[[1e9b]] – hTMK (mutant) + azido-TMP + APPNP<br />
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| **[[1e9c]] – hTMK (mutant) + dTMP + APPNP<br />
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| **[[1nmx]] – hTMK (mutant) + F-TMP + ADP<br />
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| **[[1nmy]], [[1nn0]], [[1nnz]], [[1nn1]], [[1nn3]], [[1nn5]], [[1nmz]] – hTMK (mutant) + dTMP derivative + APPNP<br />
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| **[[2xx3]] – hTMK + dTMP derivative + ADP<br />
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| **[[2yof]], [[2yog]], [[2yoh]] - TMK + thymidine analog – ''Plasmodium falciparum''<br />
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| **[[4s35]] – AaTMK + dTMP + AMPPCP<br />
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| **[[5h56]] – AaTMK + dTDP + ADP<br />
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| **[[5xb2]], [[5xb3]] – AaTMK + dTMP + ADP<br />
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| **[[5h5k]] – AaTMK + CMP + ATP<br />
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| **[[5xai]] – AaTMK + TMP <br />
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| **[[5uiv]] - TMK + TMP + ADP – ''Candida albicans''<br />
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| *Other thymidylate kinase binary complexes
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| **[[4gfd]], [[4hlc]], [[4hld]], [[4hej]], [[4hdc]] – SaTMK + antibacterial drug <br />
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| **[[4gsy]], [[4qg7]], [[4xwa]] – SaTMK + inhibitor<br />
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| **[[4qg7]], [[4qgf]], [[4qgg]], [[4qgh]] – SaTMK (mutant) + inhibitor<br />
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| **[[4mqb]] – SaTMK + MES<br />
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| **[[4unp]], [[4unq]], [[4unn]], [[4unr]], [[4uns]] – MtTMK + inhibitor<br />
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| *Thymidylate kinase complex with bisubstrate inhibitor
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| **[[1mrn]] – MtTMK + TP5A <br />
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| **[[3tmk]] – yTMK + TP5A <br />
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| **[[1e9a]] – hTMK (mutant) + azido-TP5A + ADP<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |