Superoxide Reductase: Difference between revisions

Latest revision as of 13:44, 10 December 2023

Function

Superoxide Reductase (SOR) catalyzes the conversion of reduced rubredoxin to rubredoxin using superoxide and H+. The catalysis reaction products are rubredoxin and H₂O₂^[1].

Structural highlights

The ^[2]. Water molecules are shown as red spheres.

Superoxide Reductase with Fe+3 ion (orange) complex with peroxide (red), Ca+2 ion (green) and nitrate (PDB entry 2ji3)

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3D Structures of Superoxide Reductase3D Structures of Superoxide Reductase

Updated on 10-December-2023

2ji1 – DbSOR+Fe(II)+Fe(III) – Desulfovibrio baarsii
2ji2 – DbSOR (mutant)+Fe(II)+Fe(III)
4bff – AfSOR + Fe (II) – Archaeoglobus fulgidus
4c4b, 4c4u – AfSOR (mutant) + Fe (II)
4bgl – AfSOR + Fe (III)
4bfj, 4bfk - AfSOR (mutant)+Fe(III)
2ji3 - DbSOR (mutant)+Fe(III)+peroxide
1vzg, 1vzh, 1vzi - DbSOR (mutant)+Fe(III)+Fe2(CN)6
1y07 – SOR + Fe(III) – Treponema pallidum
1dqi, 1dqk, 1do6 – SOR + Fe(III) – Pyrococcus furiosus
4d7p – SOR + Fe(III) – Giardia intestinalis
6gq8 – SOR + Fe(III) – Nanoarchaeum equitans
4brv – IhSOR + Fe (II) – Ignicoccus hospitalis
4brj, 4brv – IhSOR (mutant) + Fe (II)

ReferencesReferences

↑ Imlay JA. What biological purpose is served by superoxide reductase? J Biol Inorg Chem. 2002 Jun;7(6):659-63. Epub 2002 Apr 11. PMID:12072974 doi:http://dx.doi.org/10.1007/s00775-002-0361-3
↑ Katona G, Carpentier P, Niviere V, Amara P, Adam V, Ohana J, Tsanov N, Bourgeois D. Raman-assisted crystallography reveals end-on peroxide intermediates in a nonheme iron enzyme. Science. 2007 Apr 20;316(5823):449-53. PMID:17446401 doi:316/5823/449

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

[1] Imlay JA. What biological purpose is served by superoxide reductase? J Biol Inorg Chem. 2002 Jun;7(6):659-63. Epub 2002 Apr 11. PMID:12072974 doi:http://dx.doi.org/10.1007/s00775-002-0361-3

[2] Katona G, Carpentier P, Niviere V, Amara P, Adam V, Ohana J, Tsanov N, Bourgeois D. Raman-assisted crystallography reveals end-on peroxide intermediates in a nonheme iron enzyme. Science. 2007 Apr 20;316(5823):449-53. PMID:17446401 doi:316/5823/449

[1]

[2]

@@ Line 23: / Line 23: @@
 [[4d7p]] – SOR + Fe(III) – ''Giardia intestinalis''<br />
 [[6gq8]] – SOR + Fe(III) – ''Nanoarchaeum equitans''<br />
+[[4brv]] – IhSOR + Fe (II) – ''Ignicoccus hospitalis''<br />
+[[4brj]], [[4brv]] – IhSOR (mutant) + Fe (II) <br />
 == References ==
 <references/>
 [[Category:Topic Page]]