6u1x: Difference between revisions

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-'''Unreleased structure'''
-The entry 6u1x is ON HOLD
+==Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor (3.0 A resolution)==
+<SX load='6u1x' size='340' side='right' viewer='molstar' caption='[[6u1x]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6u1x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vesicular_stomatitis_Indiana_virus_strain_San_Juan Vesicular stomatitis Indiana virus strain San Juan]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U1X FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1x OCA], [https://pdbe.org/6u1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u1x RCSB], [https://www.ebi.ac.uk/pdbsum/6u1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1x ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/L_VSIVA L_VSIVA] RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their caping and polyadenylation (PubMed:24526687). The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor (PubMed:22908284). Caping is concommitant with initiation of mRNA transcription. The polymerase mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme (PubMed:21945214). Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.<ref>PMID:2171304</ref> <ref>PMID:21945214</ref> <ref>PMID:22246179</ref> <ref>PMID:22908284</ref> <ref>PMID:24526687</ref>   RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.<ref>PMID:2171304</ref> <ref>PMID:22246179</ref> <ref>PMID:22908284</ref> <ref>PMID:24526687</ref>
-Authors:
+==See Also==
+*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</SX>
+[[Category: Large Structures]]
+[[Category: Vesicular stomatitis Indiana virus strain San Juan]]
+[[Category: Bloyet LM]]
+[[Category: Dias-Avalos R]]
+[[Category: Grigorieff N]]
+[[Category: Harrison SC]]
+[[Category: Jenni S]]
+[[Category: Liang B]]
+[[Category: Wheelman SPJ]]