6opf: Difference between revisions

<table><tr><td colspan='2'>[[6opf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OPF FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6opf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6opf OCA], [https://pdbe.org/6opf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6opf RCSB], [https://www.ebi.ac.uk/pdbsum/6opf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6opf ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/NXF2_DROME NXF2_DROME] May be involved in the export of mRNA from the nucleus to the cytoplasm.<ref>PMID:11780633</ref> [https://www.uniprot.org/uniprot/PANX_DROME PANX_DROME] Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:26472911, PubMed:26494711). Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts (PubMed:26472911, PubMed:26494711). Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing (PubMed:26472911). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064). The interaction with nxf2 stabilizes the nuclear protein complex (PubMed:31384064).<ref>PMID:26472911</ref> <ref>PMID:26494711</ref> <ref>PMID:31219034</ref> <ref>PMID:31368590</ref> <ref>PMID:31384064</ref> <ref>PMID:31570835</ref>

[[Category: Drosophila melanogaster]]

[[Category: Patel DJ]]

[[Category: Wang J]]