2c2m: Difference between revisions
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<StructureSection load='2c2m' size='340' side='right'caption='[[2c2m]], [[Resolution|resolution]] 1.94Å' scene=''> | <StructureSection load='2c2m' size='340' side='right'caption='[[2c2m]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c2m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2M OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[2c2m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2M FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MX4:{1-[4-(BENZYLOXY)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX4</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2m OCA], [https://pdbe.org/2c2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2m RCSB], [https://www.ebi.ac.uk/pdbsum/2c2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Asgian | [[Category: Synthetic construct]] | ||
[[Category: Campbell | [[Category: Asgian JL]] | ||
[[Category: Ekici | [[Category: Campbell A]] | ||
[[Category: Ganesan | [[Category: Ekici OD]] | ||
[[Category: Gruetter | [[Category: Ganesan R]] | ||
[[Category: James | [[Category: Gruetter MG]] | ||
[[Category: Jelakovic | [[Category: James KE]] | ||
[[Category: Li | [[Category: Jelakovic S]] | ||
[[Category: Mikolajczyk | [[Category: Li ZZ]] | ||
[[Category: Powers | [[Category: Mikolajczyk J]] | ||
[[Category: Salvesen | [[Category: Powers JC]] | ||
[[Category: Salvesen GS]] | |||