Phosphocarrier protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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 <StructureSection load='' size='350' side='right' caption='Structure of phosphocarrier protein HPr (PDB entry [[1fu0]])' scene='57/570591/Cv/1'>
+__TOC__
 == Function ==
 '''Phosphocarrier protein HPr''' (HPr) is a component of the sugar phosphotransferase system.  The system catalyses the phosphorylation of sugars during their translocation across cell membrane.  A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr<ref>PMID:8246840</ref>.  A conserved histidine in the N terminal of HPr is the acceptor of the phosphate.  In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated.
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 == Structural highlights ==
 The <scene name='57/570591/Cv/3'>phosphorylation of Ser46</scene> prohibits the HPr to act as a phosphocarrier in the EI reaction<ref>PMID:11054290</ref>.
-</StructureSection>
 ==3D structures of phosphocarrier protein HPr==
+[[Phosphocarrier protein HPr 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Phosphocarrier protein HPr
-**[[2hpr]] - BsHPr (mutant) – ''Bacillus subtilis'' <br />
-**[[2hid]] - BsHPr (mutant) – NMR <br />
-**[[1jem]] - BsHPr (mutant) with phosphohistidine – NMR <br />
-**[[1sph]] – BsHPr <br />
-**[[1poh]] – EcHPr – ''Escherichia coli''  <br />
-**[[1opd]], [[1cm2]], [[1cm3]], [[3ccd]] - EcHPr (mutant)  <br />
-**[[1hdn]] - EcHPr – NMR  <br />
-**[[1pfh]] - EcHPr with phosphohistidine – NMR  <br />
-**[[1ptf]] - EfHPr – ''Enterococcus faecalis'' <br />
-**[[1qfr]] - EfHPr – NMR <br />
-**[[1fu0]] - EfHPr with phosphoserine  <br />
-**[[1pch]] – HPr – ''Mycoplasma capricolum''<br />
-**[[1qr5]] - ScHPr – ''Staphylococcus carnosus'' - NMR <br />
-**[[1txe]] - ScHPr (mutant) – NMR <br />
-**[[1ka5]] - HPr – ''Staphylococcus aureus'' - NMR <br />
-**[[1y4y]] – GsHPr – ''Geobacillus stearothermophilus''<br />
-**[[1y50]], [[1y51]] - GsHPr (mutant)  <br />
-**[[3ihs]] – HPr – ''Bacillus anthracis'' <br />
-*Phosphocarrier protein HPr complex
-**[[2jel]] - EcHPr + antibody <br />
-**[[3eze]], [[3ezb]], [[3eza]] - EcHPr + EI N terminal + PO3 – NMR  <br />
-**[[2xdf]] - EcHPr + EI N terminal – NMR  <br />
-**[[1ggr]], [[1j6t]], [[1vrc]] - EcHPr + EII N terminal + PO3 – NMR  <br />
-**[[2lrk]], [[2lrl]] - EcHPr + EII N terminal – NMR  <br />
-**[[4xwj]] - EcHPr + antisigma factor RSD  <br />
-**[[5ya0]] - EcHPr + autoinducer-2 kinase <br />
-**[[5ya1]] - EcHPr + autoinducer-2 kinase + ATP<br />
-**[[5ya2]] - EcHPr + autoinducer-2 kinase + ADP<br />
-**[[1kkl]] - BsHPr (mutant) + HPrK <br />
-**[[1kkm]] - BsHPr (mutant) with phosphoserine + HPrK/P <br />
-**[[2fep]] - BsHPr with phosphoserine + BsCcpA <br />
-**[[1rzr]] – BmHPr with phosphoserine + BmCcpA + DNA  - ''Bacillus megaterium''<br />
-**[[2oen]] - BmHPr with phosphoserine + BmCcpA<br />
-**[[2nzu]] - BmHPr with phosphoserine + BmCcpA + glucose-6-phosphate  <br />
-**[[2nzv]] - BmHPr with phosphoserine + BmCcpA + fructose-1,6-diphosphate  <br />
-**[[3oqm]], [[3oqn]], [[3oqo]] - BsHPr with phosphoserine + BsCcpA + DNA<br />
-*Phosphocarrier protein NPr
-**[[5t17]], [[5t1n]] - EcNPr – NMR  <br />
-**[[5t1o]] - EcNPr + EIN-NTR – NMR  <br />
-*Phosphocarrier protein III Glc
-**[[1f3g]] - EcPrcpIII   <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]