3dej: Difference between revisions

<table><tr><td colspan='2'>[[3dej]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DEJ FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=RXC:(1S)-1-(3-CHLOROPHENYL)-2-OXO-2-[(1,3,4-TRIOXO-1,2,3,4-TETRAHYDROISOQUINOLIN-5-YL)AMINO]ETHYL+ACETATE'>RXC</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dej OCA], [https://pdbe.org/3dej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dej RCSB], [https://www.ebi.ac.uk/pdbsum/3dej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dej ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>  

[[Category: Homo sapiens]]

[[Category: Ding J]]

[[Category: Du J]]

[[Category: Li J]]

[[Category: Wu J]]