|
|
| Line 3: |
Line 3: |
| <StructureSection load='6mnm' size='340' side='right'caption='[[6mnm]], [[Resolution|resolution]] 3.10Å' scene=''> | | <StructureSection load='6mnm' size='340' side='right'caption='[[6mnm]], [[Resolution|resolution]] 3.10Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[6mnm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MNM FirstGlance]. <br> | | <table><tr><td colspan='2'>[[6mnm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MNM FirstGlance]. <br> |
| </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), H2-Ab1, H2-iabeta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> |
| <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-arginine_deiminase Protein-arginine deiminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.15 3.5.3.15] </span></td></tr>
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mnm OCA], [https://pdbe.org/6mnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mnm RCSB], [https://www.ebi.ac.uk/pdbsum/6mnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mnm ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mnm OCA], [http://pdbe.org/6mnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mnm RCSB], [http://www.ebi.ac.uk/pdbsum/6mnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mnm ProSAT]</span></td></tr> | |
| </table> | | </table> |
| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/PADI4_MOUSE PADI4_MOUSE]] Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.<ref>PMID:15339660</ref> <ref>PMID:20733033</ref> <ref>PMID:23650392</ref> <ref>PMID:24463520</ref> | | [https://www.uniprot.org/uniprot/HA2B_MOUSE HA2B_MOUSE] |
| <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 19: |
Line 18: |
| </div> | | </div> |
| <div class="pdbe-citations 6mnm" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 6mnm" style="background-color:#fffaf0;"></div> |
| | |
| | ==See Also== |
| | *[[MHC 3D structures|MHC 3D structures]] |
| | *[[MHC II 3D structures|MHC II 3D structures]] |
| == References == | | == References == |
| <references/> | | <references/> |
| Line 24: |
Line 27: |
| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Lk3 transgenic mice]] | | [[Category: Mus musculus]] |
| [[Category: Protein-arginine deiminase]]
| | [[Category: Blevins SJ]] |
| [[Category: Blevins, S J]] | | [[Category: Huseby ES]] |
| [[Category: Huseby, E S]] | | [[Category: Stadinski BD]] |
| [[Category: Stadinski, B D]] | |
| [[Category: Immune system]]
| |
| [[Category: Major histocompatibility complex]]
| |
| [[Category: T cell receptor]]
| |