1k1g: Difference between revisions
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==STRUCTURAL BASIS FOR RECOGNITION OF THE INTRON BRANCH SITE RNA BY SPLICING FACTOR 1== | ==STRUCTURAL BASIS FOR RECOGNITION OF THE INTRON BRANCH SITE RNA BY SPLICING FACTOR 1== | ||
<StructureSection load='1k1g' size='340' side='right'caption='[[1k1g | <StructureSection load='1k1g' size='340' side='right'caption='[[1k1g]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1k1g]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1k1g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K1G FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k1g OCA], [https://pdbe.org/1k1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k1g RCSB], [https://www.ebi.ac.uk/pdbsum/1k1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k1g ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SF01_HUMAN SF01_HUMAN] Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.<ref>PMID:8752089</ref> <ref>PMID:10449420</ref> <ref>PMID:9660765</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bottomley | [[Category: Bottomley MJ]] | ||
[[Category: Houngninou-Molango | [[Category: Houngninou-Molango S]] | ||
[[Category: Kramer | [[Category: Kramer A]] | ||
[[Category: Liu | [[Category: Liu Z]] | ||
[[Category: Luyten | [[Category: Luyten I]] | ||
[[Category: Messias | [[Category: Messias AC]] | ||
[[Category: Sattler | [[Category: Sattler M]] | ||
[[Category: Sprangers | [[Category: Sprangers R]] | ||
[[Category: Zanier | [[Category: Zanier K]] | ||