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==Solution Structure of the Non-Sequence-Specific HMGB protein NHP6A in complex with SRY DNA==
==Solution Structure of the Non-Sequence-Specific HMGB protein NHP6A in complex with SRY DNA==
<StructureSection load='1j5n' size='340' side='right'caption='[[1j5n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1j5n' size='340' side='right'caption='[[1j5n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1j5n]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J5N FirstGlance]. <br>
<table><tr><td colspan='2'>[[1j5n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J5N FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cg7|1cg7]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5n OCA], [http://pdbe.org/1j5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j5n RCSB], [http://www.ebi.ac.uk/pdbsum/1j5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j5n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5n OCA], [https://pdbe.org/1j5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j5n RCSB], [https://www.ebi.ac.uk/pdbsum/1j5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j5n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NHP6A_YEAST NHP6A_YEAST]] DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6B.<ref>PMID:7721780</ref> <ref>PMID:8946917</ref> <ref>PMID:11118215</ref> <ref>PMID:11432837</ref> <ref>PMID:11239460</ref> <ref>PMID:11287614</ref> <ref>PMID:12952948</ref> <ref>PMID:14585989</ref> <ref>PMID:15082784</ref> <ref>PMID:15987999</ref> <ref>PMID:16407207</ref>
[https://www.uniprot.org/uniprot/NHP6A_YEAST NHP6A_YEAST] DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6B.<ref>PMID:7721780</ref> <ref>PMID:8946917</ref> <ref>PMID:11118215</ref> <ref>PMID:11432837</ref> <ref>PMID:11239460</ref> <ref>PMID:11287614</ref> <ref>PMID:12952948</ref> <ref>PMID:14585989</ref> <ref>PMID:15082784</ref> <ref>PMID:15987999</ref> <ref>PMID:16407207</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Allain, F H.T]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Feigon, J]]
[[Category: Allain FH-T]]
[[Category: Johnson, R C]]
[[Category: Feigon J]]
[[Category: Masse, J E]]
[[Category: Johnson RC]]
[[Category: Wong, B]]
[[Category: Masse JE]]
[[Category: Yen, Y M]]
[[Category: Wong B]]
[[Category: Alpha helix]]
[[Category: Yen Y-M]]
[[Category: Dna binding protein-dna complex]]
[[Category: Double helix]]
[[Category: Hmg-box]]
[[Category: Hmgb]]
[[Category: Protein-dna complex]]

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