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==PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1171217421== | |||
<StructureSection load='5qqr' size='340' side='right'caption='[[5qqr]], [[Resolution|resolution]] 1.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qqr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QQR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NSV:1-[(2-methyl-1,3-thiazol-5-yl)methyl]piperazine'>NSV</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qqr OCA], [https://pdbe.org/5qqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qqr RCSB], [https://www.ebi.ac.uk/pdbsum/5qqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qqr ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] | ||
[[Category: | == References == | ||
[[Category: Edwards | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bailey H]] | ||
[[Category: | [[Category: Bezerra GA]] | ||
[[Category: Bountra C]] | |||
[[Category: Brandao-Neto J]] | |||
[[Category: Brennan PE]] | |||
[[Category: Douangamath A]] | |||
[[Category: Edwards A]] | |||
[[Category: Foster W]] | |||
[[Category: Krojer T]] | |||
[[Category: Nicola BB]] | |||
[[Category: Shrestha L]] | |||
[[Category: Talon R]] | |||
[[Category: Yue WW]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 13:11, 14 February 2024
PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1171217421PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1171217421
Structural highlights
DiseaseHEM0_HUMAN X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).[1] FunctionReferences
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