Formate dehydrogenase: Difference between revisions

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</StructureSection>
</StructureSection>
==3D structure of formate dehydrogenase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*NAD-dependent FDH
**[[2nac]], [[2go1]] – PsFDH – ''Pseudomonas''<BR />
**[[2fss]], [[5dna]] – CbFDH – ''Candida boidinii''<BR />
**[[2j6i]] – CbFDH C terminal (mutant) <BR />
**[[3fn4]] - MoFDH – ''Moraxella''<BR />
**[[3naq]], [[3jtm]] – ArFDH – ''Arabidopsis thaliana''<BR />
**[[2nad]] – PsFDH + NAD<BR />
**[[2gug]] – PsFDH + formate<BR />
**[[2gsd]] – MoFDH + NAD + N3<BR />
**[[3n7u]] - ArFDH + NAD + N3<BR />
**[[5dn9]] - CbFDH + NAD + N3<BR />
**[[6d4b]], [[6d4c]] – CbFDH (mutant) + NAD + N3<br />
**[[3wr5]] – FDH + NAD – ''Thiobacillus''<br />
**[[4xyg]] – GmFDH – ''Granulicella mallensis''<br />
**[[4xyb]] – GmFDH + NADP <br />
**[[4xye]] – GmFDH + NAD<br />
**[[1qp8]] – FDH + NADP – ''Pyrobaculum aerophilum''<br />
*Mo-dependent FDH
**[[1aa6]], [[1fdo]], [[2iv2]] – EcFDH-H + Fe4S4 + MGD – ''Escherichia coli''<BR />
**[[1fdi]] - EcFDH-H + Fe4S4 + NO2 + MGD<BR />
**[[1kqf]] - EcFDH-N + Fe4S4 + protoporphyrin + MGD<BR />
**[[1kqg]] - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD<BR />
**[[1h0h]] - FDH + Fe4S4 +MGD – ''Desulfovibrio gigas''
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 12:27, 3 July 2019


Formate dehydrogenase (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe4S4 center and then to cytochrome. The Mo-dependent FDH-H from E. coli contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe4S4[1].

  • in NAD-dependent formate dehydrogenase (2nad). Water molecules shown as red spheres.
  • .

3D structure of formate dehydrogenase

Formate dehydrogenase 3D structures


NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, 2nad

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Ferry JG. Formate dehydrogenase. FEMS Microbiol Rev. 1990 Dec;7(3-4):377-82. PMID:2094290

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Michal Harel, Alexander Berchansky, Joel L. Sussman
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