Kdo-8-phosphate synthase: Difference between revisions
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== Function == | == Function == | ||
'''Kdo-8-phosphate synthase''' (KPS) catalyzes the formation of the phosphorylated rare sugar Kdo-8-phosphate (Kdo-8-P) from phosphoenolpyruvate (PEP) and D-arabinose-5-phosphate (A5P). Some bacteria like ''Aquifex aeolicus'' have '''Metallo KPS''' which is a metal-requiring enzyme while others like ''E.coli'' have a '''Non-metallo KPS''' which does not require a divalent cation for its activity. Kdo-8-P is found in cell walls of higher plants and some green algae<ref>PMID:11904225</ref>. | '''Kdo-8-phosphate synthase''' or '''2-dehydro-3-deoxyphosphooctonate aldolase''' (KPS) catalyzes the formation of the phosphorylated rare sugar Kdo-8-phosphate (Kdo-8-P) from phosphoenolpyruvate (PEP) and D-arabinose-5-phosphate (A5P). Some bacteria like ''Aquifex aeolicus'' have '''Metallo KPS''' which is a metal-requiring enzyme while others like ''E.coli'' have a '''Non-metallo KPS''' which does not require a divalent cation for its activity. Kdo-8-P is found in cell walls of higher plants and some green algae<ref>PMID:11904225</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
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*Non-metallo Kdo8P | *Non-metallo Kdo8P | ||
**[[1d9e]], [[1gg0]], [[1x8f]] – EcKPS - ''Escherichia coli''<br /> | **[[1d9e]], [[1gg0]], [[1x8f]], [[6u57]] – EcKPS - ''Escherichia coli''<br /> | ||
**[[1o60]] - KPS – ''Haemophilus influenza''<br /> | **[[1o60]] - KPS – ''Haemophilus influenza''<br /> | ||
**[[3e9a]] - KPS – ''Vibrio cholerae''<br /> | **[[3e9a]] - KPS – ''Vibrio cholerae''<br /> | ||
**[[3fs2]] - KPS – ''Brucella melitensis''<br /> | **[[3fs2]] - KPS – ''Brucella melitensis''<br /> | ||
**[[3t4c]], [[3tml]] - KPS – ''Burkholderia ambifaria'' | **[[3t4c]], [[3tml]] - KPS – ''Burkholderia ambifaria''<br /> | ||
**[[6mdy]] – KPS – ''Legionella pneumophila''<br /> | |||
*''Non-metallo Kdo8P binary complex'' | *''Non-metallo Kdo8P binary complex'' | ||