6s1f: Difference between revisions

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-'''Unreleased structure'''
-The entry 6s1f is ON HOLD
+==Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3==
+<StructureSection load='6s1f' size='340' side='right'caption='[[6s1f]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6s1f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S1F FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KRE:~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide'>KRE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s1f OCA], [https://pdbe.org/6s1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s1f RCSB], [https://www.ebi.ac.uk/pdbsum/6s1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s1f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RIPK2_HUMAN RIPK2_HUMAN] Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.<ref>PMID:14638696</ref> <ref>PMID:17054981</ref> <ref>PMID:18079694</ref> <ref>PMID:21123652</ref>
-Authors: Pinkas, D.M., Bufton, J.C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
+==See Also==
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-Description: Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Burgess-Brown, N.A]]
+__TOC__
-[[Category: Pinkas, D.M]]
+</StructureSection>
-[[Category: Bountra, C]]
+[[Category: Homo sapiens]]
-[[Category: Kupinska, K]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Arrowsmith CH]]
-[[Category: Von Delft, F]]
+[[Category: Bountra C]]
-[[Category: Bullock, A.N]]
+[[Category: Bufton JC]]
-[[Category: Bufton, J.C]]
+[[Category: Bullock AN]]
-[[Category: Edwards, A.M]]
+[[Category: Burgess-Brown NA]]
+[[Category: Edwards AM]]
+[[Category: Kupinska K]]
+[[Category: Pinkas DM]]
+[[Category: Von Delft F]]