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==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==
==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==
<StructureSection load='1ckw' size='340' side='right'caption='[[1ckw]], [[NMR_Ensembles_of_Models | 13 NMR models]]' scene=''>
<StructureSection load='1ckw' size='340' side='right'caption='[[1ckw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ckw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKW FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ckw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKW FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckw OCA], [http://pdbe.org/1ckw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ckw RCSB], [http://www.ebi.ac.uk/pdbsum/1ckw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckw ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckw OCA], [https://pdbe.org/1ckw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckw RCSB], [https://www.ebi.ac.uk/pdbsum/1ckw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP]] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).  
[https://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ko, Y H]]
[[Category: Ovis aries]]
[[Category: Massiah, M A]]
[[Category: Ko YH]]
[[Category: Mildvan, A S]]
[[Category: Massiah MA]]
[[Category: Pedersen, P L]]
[[Category: Mildvan AS]]
[[Category: Cystic fibrosis]]
[[Category: Pedersen PL]]
[[Category: Metal transport]]
[[Category: P25_tfe]]
[[Category: Peptide]]

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