Cyclin: Difference between revisions
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'''Cyclin''' (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that different CYCs are expressed during different phases of the cell cycle. Among the CYCs:<br /> | '''Cyclin''' (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that different CYCs are expressed during different phases of the cell cycle. Among the CYCs:<br /> | ||
* '''CYCA''' is active in the S phase<br /> | * '''CYCA''' is active in the S phase<br /> | ||
* '''CYCA2''' regulates DNA replication and mitotic entry.<ref>PMID:33402344</ref><br /> | |||
* '''CYCB1''' is essential for the control of the cell cycle at the G2/M (mitosis) transition.<br /> | * '''CYCB1''' is essential for the control of the cell cycle at the G2/M (mitosis) transition.<br /> | ||
* '''CYCC''' is active in the G0/G1 phase transition<ref>PMID:12910258</ref>.br /> | * '''CYCC''' is active in the G0/G1 phase transition<ref>PMID:12910258</ref>.<br /> | ||
* '''CYCCCL1''' controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription <ref>PMID:8761664</ref><br /> | |||
* '''CYCD''' regulates the transition from G1 to S.<ref>PMID:15130482</ref><br /> | * '''CYCD''' regulates the transition from G1 to S.<ref>PMID:15130482</ref><br /> | ||
* '''CYCE''' and its CDK partner are key regulators of DNA synthesis and of mitosis.<ref>PMID:11907280</ref><br /> | * '''CYCE''' and its CDK partner are key regulators of DNA synthesis and of mitosis.<ref>PMID:11907280</ref><br /> | ||
* '''CYCF''' is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex<ref>PMID:28652210</ref><br /> | |||
* '''CYCH''' is highly expressed in ovarian cancer<ref>PMID:32694938</ref><br /> | |||
* '''CYCK''' and its CDK12 partner regulate the expression of DNA-damage response genes and thus protect cells from genomic instability.<ref>PMID:22012619</ref><br /> | * '''CYCK''' and its CDK12 partner regulate the expression of DNA-damage response genes and thus protect cells from genomic instability.<ref>PMID:22012619</ref><br /> | ||
* '''CYCT''' and its CDK9 partner regulate gene expression.<ref>PMID:15276198</ref><br /> | * '''CYCT''' and its CDK9 partner regulate gene expression.<ref>PMID:15276198</ref><br /> | ||