Complement C3: Difference between revisions

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 == Function ==
-'''Complement C3''' (CC3) activates the complement system which is part of the immune response.  CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663).  C3a is a mediator of local inflammatory processes.  C3b binds covalently to cell surface carbohydrates or immune aggregates.  Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells.  C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>
+'''Complement C3''' (CC3) activates the complement system which is part of the immune response.  '''CC3''' is proteolytically cleaved by C3 convertase to '''C3a''' (residues 672-748) and '''C3b''' (residues 23-667, 749-1663).
+*'''C3a''' is a mediator of local inflammatory processes.
+*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.
+*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>
+*'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells<ref>PMID:17337780</ref>.
 <scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.