Cholesterol esterase: Difference between revisions

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</StructureSection>
</StructureSection>
==3D structures of cholesterol esterase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Cholesterol esterase
**[[1jmy]] – hChoE catalytic domain- human<br />
**[[1f6w]], [[6h0t]] – hChoE catalytic domain (mutant) <br />
**[[1akn]] – bChoE – bovine<br />
**[[2bce]] – bChoE (mutant)<br />
**[[4be9]], [[4be4]] – OpChoE – ''Ophiostoma piceae''<br />
**[[4upd]] – OpChoE (mutant) <br />
*Cholesterol esterase complex
**[[6h0v]] – hChoE (mutant) + tabun<br />
**[[6h18]] – hChoE (mutant) + sarin<br />
**[[6h19]] – hChoE (mutant) + paraoxon<br />
**[[6h1a]] – hChoE (mutant) + VX<br />
**[[1aql]] – bChoE + taurocholate<br />
**[[1cle]] – CcChoE + cholesteryl linoleate – ''Candida cylindracea''<br />
**[[1llf]] – CcChoE + tricosanoic acid<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 13:17, 12 May 2019

Function

Cholesterol esterase (ChoE) also named bile-salt activated lipase or sterol esterase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.[1]

Disease

Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.

Structural highlights

ChoE (Hydrophobic, Polar). ChoE has the at the opening and .[2]

3D structures of cholesterol esterase

Cholesterol esterase 3D structures


Glycosylated cholesterol esterase dimer complex with bile acid (PDB entry 1llf)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Moore SA, Kingston RL, Loomes KM, Hernell O, Blackberg L, Baker HM, Baker EN. The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding. J Mol Biol. 2001 Sep 21;312(3):511-23. PMID:11563913 doi:10.1006/jmbi.2001.4979
  2. ↑ Pletnev V, Addlagatta A, Wawrzak Z, Duax W. Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution. Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):50-6. Epub 2002 Dec, 19. PMID:12499539

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Michal Harel, Alexander Berchansky
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