5o57: Difference between revisions

<StructureSection load='5o57' size='340' side='right'caption='[[5o57]], [[NMR_Ensembles_of_Models | 70 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[5o57]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O57 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DKK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o57 OCA], [http://pdbe.org/5o57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o57 RCSB], [http://www.ebi.ac.uk/pdbsum/5o57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o57 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/DKK4_HUMAN DKK4_HUMAN]] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).  

[[Category: Human]]

[[Category: Barkell, A M]]

[[Category: Carr, M D]]

[[Category: Holdsworth, G]]

[[Category: Muskett, F W]]

[[Category: Patel, S]]

[[Category: Robinson, M K]]

[[Category: Waters, L C]]

[[Category: Wnt signalling]]