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| • '''CENP-B''' facilitates centromere formation.<ref>PMID:11726497</ref><br /> | | • '''CENP-B''' facilitates centromere formation.<ref>PMID:11726497</ref><br /> |
| • '''CENP-A''' is a component of modified nucleosome replacing hitone H3.<ref>PMID:20739937</ref><br /> | | • '''CENP-A''' is a component of modified nucleosome replacing hitone H3.<ref>PMID:20739937</ref><br /> |
| • '''CENP-E''' is a motor protein involved inchromosome movement.<ref>PMID:15159587</ref><br /> | | • '''CENP-E''' is a motor protein involved in chromosome movement.<ref>PMID:15159587</ref><br /> |
| | • '''CENP-I''' regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal.<br /> |
| • '''CENP-M''' and '''CENP-N''' are involved in the kinetochore assembly.<ref>PMID:25006165</ref><br /> | | • '''CENP-M''' and '''CENP-N''' are involved in the kinetochore assembly.<ref>PMID:25006165</ref><br /> |
| | • '''Kinetochore''' is a complex essential for accurate chromosome segregation.<ref>PMID:16214339</ref><br /> |
| • '''CENP-mis12''' from fission yeast is required for correct spindle morphogenesis<ref>PMID:10398680</ref>.<br /> | | • '''CENP-mis12''' from fission yeast is required for correct spindle morphogenesis<ref>PMID:10398680</ref>.<br /> |
| * '''Inner centromere protein''' (INCENP) is a component of the chromosomal passenger complex which regulates mitosis. INCENP are localized at the centromeres during mid-metaphase of the cell cycle.<ref>PMID:17956729</ref> | | * '''Inner centromere protein''' (INCENP) is a component of the chromosomal passenger complex which regulates mitosis. INCENP are localized at the centromeres during mid-metaphase of the cell cycle.<ref>PMID:17956729</ref> |
| | • '''CBF3''' is a yeast complex which interacts with centromeric DNA and mediates nucleosome deposition.<ref>PMID:30478265</ref><br /> |
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| == Disease == | | == Disease == |
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| </StructureSection> | | </StructureSection> |
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| ==3D structures of centromere protein==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Centromere proteins X, S, W, T
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| **[[3b0b]] – cCENP-X + CENP-S – chicken<br />
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| **[[4dra]], [[4e44]], [[4ne3]], [[4ne5]], [[4ne6]] – hCENP-X + CENP-S – human<br />
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| **[[3vh5]], [[3vh6]] – cCENP-X + CENP-S (mutant) + CENP-W + CENP-T C-terminal (mutant)<br />
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| **[[4drb]], [[4e45]] – hCENP-X + CENP-S + Fanconi anemia group M protein<br />
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| **[[4ndy]], [[4ne1]] – hCENP-X + CENP-S + DNA<br />
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| **[[3b0c]], [[3b0d]] – cCENP-T + CENP-W<br />
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| **[[3vza]] – cCENP-T residues 63-98 (mutant) + Spc24 + Spc25<br />
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| *Inner centromere protein
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| **[[2bfx]], [[4b8l]] – fINCENP residues 798-840 + aurora kinase – frog<br />
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| **[[2bfy]] – fINCENP residues 798-840 + aurora kinase + hesperadin<br />
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| **[[2vgp]], [[2vrx]], [[3ztx]], [[4b8m]], [[5k3y]], [[5eyk]] – fINCENP residues 798-840 + aurora kinase + inhibitor<br />
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| **[[4af3]] – hINCENP residues 835-903 + aurora kinase + inhibitor<br />
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| **[[2vgo]] – fINCENP residues 798-840 + aurora kinase + reversine<br />
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| **[[4c2v]] – fINCENP residues 798-840 + aurora kinase + barasertib<br />
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| **[[4c2w]] – fINCENP residues 798-840 + aurora kinase + AMPPNP<br />
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| **[[2qfa]] – hINCENP residues 1-47 + surviving + borealin<br />
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| *Centromere protein A
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| **[[3nqu]] – hCENP-A + histone H4<br />
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| **[[3nqj]] – hCENP-A residues 60-140 + histone H4<br />
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| **[[3r45]] – hCENP-A + histone H4 + Holliday junction recognition protein<br />
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| **[[3an2]] – hCENP-A + histone H4 + histone H2A + histone H2B + DNA<br />
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| **[[6buz]] – hCENP-A + histone H4 + histone H2A + histone H2B + DNA + MBP/CENP-N<br />
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| *Centromere protein C
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| **[[5lsk]], [[5lsj]] – hCENP-C + kinetochore MIS12<br />
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| *Centromere protein B
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| **[[1bw6]] – hCENP-B DNA-binding domain - NMR<br />
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| **[[1ufi]] – hCENP-B dimerization domain <br />
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| **[[1hlv]] – hCENP-B DNA-binding domain + DNA<br />
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| *Centromere protein E
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| **[[1t5c]] – hCENP-E motor domain<br />
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| *Centromere protein I
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| **[[5z07]] – CtCENP-I – ''Chaetomium thermophilum''<br />
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| *Centromere protein J
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| **[[5itz]] – hCENP-J + tubulin<br />
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| *Centromere protein M
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| **[[4p0t]], [[4wau]] – hCENP-M<br />
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| *Centromere protein N
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| **[[4wau]], [[6eqt]] – hCENP-N<br />
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| **[[6c0w]] – hCENP-N + histone H4 + histone H2A + histone H2B + DNA + CENP-A<br />
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| *Centromere protein I+K+H
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| **[[5z08]] – CtCENP-I + CENP-K + CENP-H <br />
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| *Centromere protein mis12
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| **[[5wwl]] – fyCENP + kinetochore protein NNF1 – fission yeast<br />
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| *Centromere protein mis16
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| **[[5wjc]] – fyCENP + EIC1<br />
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| }}
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| == References == | | == References == |