Cellular retinoic acid-binding protein: Difference between revisions

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Molecular Playground banner: CRABP I, a carrier protein for retinoic acid, has an important role for vision.
Molecular Playground banner: CRABP I, a carrier protein for retinoic acid, has an important role for vision.


 
__TOC__
==Function==


'''Cellular Retinoic Acid Binding Proteins''' ('''CRABPs''') are small intracellular proteins (15.5
'''Cellular Retinoic Acid Binding Proteins''' ('''CRABPs''') are small intracellular proteins (15.5
kDa) that belong to the family of intracellular lipid binding proteins (iLBP) which bind
kDa) that belong to the family of intracellular lipid binding proteins (iLBP) which bind
small hydrophobic ligands. There are two types of CRABPs, CRABP I and CRABP II. They seem to play a role in controlling Retinoic Acid(RA)-mediated differentiation and proliferation processes [http://www.ncbi.nlm.nih.gov/pubmed/8756459?dopt=Abstract/]. During embryonic development, the spatial and temporal expression of the CRABP gene appears to be strictly regulated [http://www.ncbi.nlm.nih.gov/pubmed/2547683]. Therefore, it has been suggested that CRABP could be involved in the formation of gradients of RA across various developing tissues. Although the structure of CRABP I is similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. '''Epididymal RABP (ERABP)''' is an androgen-dependent RABP present in the lumen of the epididymis believed to be involved in sperm maturation.  ERABP binds specifically all-trans- and 9-cis-RA.  
small hydrophobic ligands. There are two types of CRABPs, CRABP I and CRABP II. They seem to play a role in controlling Retinoic Acid(RA)-mediated differentiation and proliferation processes [http://www.ncbi.nlm.nih.gov/pubmed/8756459?dopt=Abstract/]. During embryonic development, the spatial and temporal expression of the CRABP gene appears to be strictly regulated [http://www.ncbi.nlm.nih.gov/pubmed/2547683]. Therefore, it has been suggested that CRABP could be involved in the formation of gradients of RA across various developing tissues. Although the structure of CRABP I is similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. '''Epididymal RABP (ERABP)''' is an androgen-dependent RABP present in the lumen of the epididymis believed to be involved in sperm maturation.  ERABP binds specifically all-trans- and 9-cis-RA.  
*'''CRABP I''' is expressed during embryogenesis and also in adult tissues.
*'''CRABP II''' is expressed in skin embryogenesis.
*'''CRABP IV''' promotes oxidative stress by decreasing endothelial mitochondrial function.
==Structure==
==Structure==


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* [http://en.wikipedia.org/wiki/CRABP1 Cellular retinoic acid-binding protein 1 at Wikipedia]
* [http://en.wikipedia.org/wiki/CRABP1 Cellular retinoic acid-binding protein 1 at Wikipedia]


==3D structure of cellular retinoic acid-binding protein==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*CRABP I
**[[2cbr]], [[1cbi]] - hCRABP I – human<br />
**[[1cbr]] - CRABP  I + retinoic acid – mouse
*CRABP II
**[[2fs6]], [[2fs7]] - hCRABP II<br />
**[[1xca]] - hCRABP II (mutant) <br />
**[[1blr]] - hCRABP II – NMR<br />
**[[1bm5]] - hCRABP II (mutant) – NMR<br />
**[[3fek]], [[3fel]], [[3fen]], [[3fa7]], [[3fa8]], [[3fa9]], [[3i17]], [[3d95]], [[3d96]], [[3d97]], [[2frs]] - hCRABP II (mutant) <br />
**[[3f8a]], [[3f9d]], [[3fa6]], [[3cr6]], [[2g79]], [[2g7b]], [[4qgw]], [[4qgx]] – hCRABP II (mutant) + retinal analog<br />
**[[4ybp]], [[4ybu]], [[4yce]], [[4ych]], [[4yda]], [[4ydb]], [[4yfp]], [[4yfq]], [[4yfr]], [[4ygg]], [[4ygh]], [[4ygz]], [[4yh0]], [[4ykm]], [[4yko]],[[6mop]], [[6moq]], [[6mor]], [[6mov]], [[6mox]], [[6mpk]], [[6mqi]], [[6mqj]], [[6mqw]], [[6mqx]], [[6mqy]], [[6mqz]], [[6mr0]], [[6nnx]], [[6nny]], [[6noe]] – hCRABP II (mutant) + retinal <br />
**[[3cwk]], [[2g78]], [[4i9r]], [[4i9s]], [[4m6s]], [[4m7m]] – hCRABP II (mutant) + retinoic acid<br />
**[[2fr3]], [[2cbs]], [[3cbs]], [[1cbq]], [[1cbs]] – hCRABP II + retinoic acid<br />
**[[3fep]] - hCRABP II (mutant) + ligand<br />
**[[5hzq]] - hCRABP II + arylfluorosulfate<br />
**[[4qgv]] - hCRABP II (mutant) + merocyanine<br />
*CRABP IV
**[[1lpj]], [[6at8]] - hCRABP IV<br />
**[[6e6k]] - hCRABP IV + canabidiol<br />
*ERABP
**[[1epa]] – rERABP – rat<br />
**[[1epb]] – rERABP + RA
}}
==References==
==References==


Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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