Ras Protein and Pancreas Cancer: Difference between revisions
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==Introduction== | ==Introduction== | ||
<StructureSection load='1ctq' size='340' side='right' caption=' | <StructureSection load='1ctq' size='340' side='right' caption='Human GTPase HRas complex wih GMP and Ng+2 ion (green) (PDB code [[1ctq]])' scene=''> | ||
Ras proteins are the founding members of a large superfamily of monomeric small GTPases. These proteins are best known for their ability to serve as molecular switches regulating diverse cellular processes that include cell cycle progression, cell survival, actin cytoskeletal organization, cell polarity and movement, and vesicular and nuclear transport <ref name=Gervaise>doi:10.1002/bip.22840</ref>. Both unicellular and multicellular organisms express Ras proteins. The human Ras superfamily is divided into five major branches: Ras proteins, Rho, Ran, Rab, and “unclassified” sequences <ref name='Gervaise'>doi:10.1002/bip.22840</ref>. Even though these are separated branches, they share a lot of similarities not only in their structure but also in their functions. | Ras proteins are the founding members of a large superfamily of monomeric small GTPases. These proteins are best known for their ability to serve as molecular switches regulating diverse cellular processes that include cell cycle progression, cell survival, actin cytoskeletal organization, cell polarity and movement, and vesicular and nuclear transport <ref name=Gervaise>doi:10.1002/bip.22840</ref>. Both unicellular and multicellular organisms express Ras proteins. The human Ras superfamily is divided into five major branches: Ras proteins, Rho, Ran, Rab, and “unclassified” sequences <ref name='Gervaise'>doi:10.1002/bip.22840</ref>. Even though these are separated branches, they share a lot of similarities not only in their structure but also in their functions. | ||