4rmh: Difference between revisions

<table><tr><td colspan='2'>[[4rmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RMH FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TE:2-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYL]-N-[5-(NAPHTHALEN-1-YLMETHYL)-1,3-THIAZOL-2-YL]ACETAMIDE'>3TE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmh OCA], [https://pdbe.org/4rmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rmh RCSB], [https://www.ebi.ac.uk/pdbsum/4rmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rmh ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>  

*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Einsle O]]

[[Category: Gajer M]]

[[Category: Gerhardt S]]

[[Category: Jung M]]

[[Category: Karaman B]]

[[Category: Ladwein KI]]

[[Category: Lehotzky A]]

[[Category: North BJ]]

[[Category: Olah J]]

[[Category: Ovadi J]]

[[Category: Pannek M]]

[[Category: Roessler C]]

[[Category: Rumpf T]]

[[Category: Schiedel M]]

[[Category: Schmidtkunz K]]

[[Category: Schutkowski M]]

[[Category: Sinclair DA]]

[[Category: Sippl W]]

[[Category: Steegborn C]]