6odb: Difference between revisions

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-'''Unreleased structure'''
-The entry 6odb is ON HOLD  until Paper Publication
+==Crystal structure of HDAC8 in complex with compound 3==
+<StructureSection load='6odb' size='340' side='right'caption='[[6odb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6odb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ODB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=M8G:N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide'>M8G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odb OCA], [https://pdbe.org/6odb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6odb RCSB], [https://www.ebi.ac.uk/pdbsum/6odb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6odb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref>
-Authors: Zheng, X., Conti, C., Caravella, J., Zablocki, M.-M., Bair, K., Barczak, N., Han, B., Lancia Jr., D., Liu, C., Martin, M., Ng, P.Y., Rudnitskaya, A., Thomason, J.J., Garcia-Dancey, R., Hardy, C., Lahdenranta, J., Leng, C., Li, P., Pardo, E., Saldahna, A., Tan, T., Toms, A.V., Yao, L., Zhang, C.
+==See Also==
+*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
-Description: Crystal structure of HDAC8 in complex with compound 3
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Tan, T]]
+__TOC__
-[[Category: Rudnitskaya, A]]
+</StructureSection>
-[[Category: Leng, C]]
+[[Category: Homo sapiens]]
-[[Category: Barczak, N]]
+[[Category: Large Structures]]
-[[Category: Lancia Jr]]
+[[Category: Bair K]]
-[[Category: Han, B]]
+[[Category: Barczak N]]
-[[Category: Zablocki, M.-M]]
+[[Category: Caravella J]]
-[[Category: Yao, L]]
+[[Category: Conti C]]
-[[Category: Martin, M]]
+[[Category: Garcia-Dancey R]]
-[[Category: Bair, K]]
+[[Category: Han B]]
-[[Category: Toms, A.V]]
+[[Category: Hardy C]]
-[[Category: Pardo, E]]
+[[Category: Lahdenranta J]]
-[[Category: Zheng, X]]
+[[Category: Lancia Jr D]]
-[[Category: Liu, C]]
+[[Category: Leng C]]
-[[Category: Conti, C]]
+[[Category: Li P]]
-[[Category: Hardy, C]]
+[[Category: Liu C]]
-[[Category: Lahdenranta, J]]
+[[Category: Martin M]]
-[[Category: Caravella, J]]
+[[Category: Ng PY]]
-[[Category: Saldahna, A]]
+[[Category: Pardo E]]
-[[Category: Garcia-Dancey, R]]
+[[Category: Rudnitskaya A]]
-[[Category: Zhang, C]]
+[[Category: Saldahna A]]
-[[Category: D]]
+[[Category: Tan T]]
-[[Category: Li, P]]
+[[Category: Thomason JJ]]
-[[Category: Ng, P.Y]]
+[[Category: Toms AV]]
-[[Category: Thomason, J.J]]
+[[Category: Yao L]]
+[[Category: Zablocki M-M]]
+[[Category: Zhang C]]
+[[Category: Zheng X]]