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| <StructureSection load='4qv2' size='340' side='right'caption='[[4qv2]], [[Resolution|resolution]] 1.68Å' scene=''> | | <StructureSection load='4qv2' size='340' side='right'caption='[[4qv2]], [[Resolution|resolution]] 1.68Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[4qv2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_cat/giv.2/cu081210e/usa/2010 Norovirus cat/giv.2/cu081210e/usa/2010]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QV2 FirstGlance]. <br> | | <table><tr><td colspan='2'>[[4qv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_cat/GIV.2/CU081210E/USA/2010 Norovirus cat/GIV.2/CU081210E/USA/2010]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QV2 FirstGlance]. <br> |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68Å</td></tr> |
| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4quz|4quz]], [[4qva|4qva]]</td></tr>
| | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JF781268 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1160949 Norovirus cat/GIV.2/CU081210E/USA/2010])</td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qv2 OCA], [https://pdbe.org/4qv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qv2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qv2 ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qv2 OCA], [http://pdbe.org/4qv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qv2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qv2 ProSAT]</span></td></tr> | |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| | == Function == |
| == Publication Abstract from PubMed == | | [https://www.uniprot.org/uniprot/H8YRY9_9CALI H8YRY9_9CALI] |
| Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35A resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain alpha-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus.
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| Structural analysis of a feline norovirus protruding domain.,Singh BK, Glatt S, Ferrer JL, Koromyslova AD, Leuthold MM, Dunder J, Hansman GS Virology. 2015 Jan 1;474:181-5. doi: 10.1016/j.virol.2014.10.028. Epub 2014 Nov, 19. PMID:25463616<ref>PMID:25463616</ref>
| | ==See Also== |
| | | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] |
| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 4qv2" style="background-color:#fffaf0;"></div>
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| == References == | |
| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Norovirus cat/giv 2/cu081210e/usa/2010]] | | [[Category: Norovirus cat/GIV 2/CU081210E/USA/2010]] |
| [[Category: Hansman, G S]] | | [[Category: Hansman GS]] |
| [[Category: Singh, B K]] | | [[Category: Singh BK]] |
| [[Category: Capsid protein]]
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| [[Category: Feline norovirus]]
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| [[Category: P domain]]
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| [[Category: Protruding domain]]
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| [[Category: Viral protein]]
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