Bungarotoxin: Difference between revisions

Latest revision as of 11:21, 18 April 2019

Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.

α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in Alpha-bungarotoxin.
β-BGT binds to the presynaptic terminal causing release of acetylcholine.
γ-BGT inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor.
κ-BGT binds weakly to the nicotinic acetylcholine receptor.

For toxins in Proteopedia see Toxins.

in α-Bungarotoxin (PDB code 1hc9).^[1] Water molecule shown as red sphere.

α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code 1hc9)

Drag the structure with the mouse to rotate

↑ Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996

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 </StructureSection>
-== 3D Structures of Bungarotoxin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-* Bungarotoxin
-**[[2abx]] – α-BGT <br />
-**[[1kfh]], [[1ik8]], [[1ikc]], [[1idi]], [[1idl]], [[2nbt]] – α−BGT – NMR<br />
-**[[1bun]] - β2-BGT<br />
-**[[1mr6]] – γ-BGT – NMR<br />
-**[[1kba]] – κ-BGT<br />
-* BGT+binding peptide
-**[[1l4w]], [[1ljz]], [[1kc4]], [[1kl8]], [[1jbd]], [[1haa]], [[1haj]], [[1idg]], [[1idh]], [[1hoy]], [[1bxp]], [[1abt]], [[1rgj]], [[2btx]] – α-BGT+AChR peptide - NMR<br />
-**[[1hc9]] - α-BGT+AChR peptide<br />
-* BGT+ AChR subunit
-**[[2qc1]] – α-BGT+mAChR α subunit <br />
-**[[5hbt]] - α-BGT+ hAChR α1 subunit + antibody<br />
-**[[5hbv]] - α-BGT+ mAChR α1 subunit + antibody<br />
-**[[4hqp]] - α−BGT+ hAChR α7 subunit<br />
-**[[4uy2]] - α−BGT+ hAChR α9 subunit<br />
-}}
 == References ==
 <references/>