Bromodomain-containing protein: Difference between revisions
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'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>. | '''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>. | ||
*'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>. | |||
For detalis on BRD3 see [[Human bromodomain containing protein 3]] | *'''BRD2''' promotes spatial mixing and compartmentalisation of chromatin<ref>PMID:35410381</ref>. | ||
*'''BRD3''' and '''BRD4''' regulate skeletal myogenesis<ref>PMID:28733670</ref>. For detalis on BRD3 see [[Human bromodomain containing protein 3]] | |||
*'''BRD7''' promotes colorectal cancer by regulating the ubiquitin-proteasome-dependent stabilisation of c-Myc protein<ref>PMID:34109174</ref>. | |||
*'''BRD9''' has a role in activation of interferon-stimulated genes<ref>PMID:34983841</ref>. | |||
== Disease == | == Disease == | ||