6mdv: Difference between revisions

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 <StructureSection load='6mdv' size='340' side='right'caption='[[6mdv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6mdv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MDV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MDV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6mdv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MDV FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ndoS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mdv OCA], [http://pdbe.org/6mdv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mdv RCSB], [http://www.ebi.ac.uk/pdbsum/6mdv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mdv ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mdv OCA], [https://pdbe.org/6mdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mdv RCSB], [https://www.ebi.ac.uk/pdbsum/6mdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mdv ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ENDS2_STRP9 ENDS2_STRP9] Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection (PubMed:23865566, PubMed:27288408, PubMed:26156869, PubMed:30937380). Specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the complex-type N-linked glycan located on 'Asn-297' of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 or IGHG4), thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway (By similarity). Also able to cleave biantennary and sialylated glycans of host alpha-1-acid glycoprotein (ORM1 or ORM2) (PubMed:23865566, PubMed:27288408). Acts on N-linked glycans with or without core fucosylation (PubMed:26156869, PubMed:27288408, PubMed:30937380). In contrast to EndoS, also able to process oligomannose- or hybrid-type glycans (PubMed:26156869, PubMed:30937380). Specifically acts on IgGs; does not act on immunoglobulin alpha, beta, delta or mu (PubMed:26156869).[UniProtKB:Q99Y92]<ref>PMID:23865566</ref> <ref>PMID:26156869</ref> <ref>PMID:27288408</ref> <ref>PMID:30937380</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Micrococcus scarlatinae klein 1884]]
 [[Category: Large Structures]]
-[[Category: Guerin, M E]]
+[[Category: Streptococcus pyogenes]]
-[[Category: Klontz, E H]]
+[[Category: Guerin ME]]
-[[Category: Orwenyo, J]]
+[[Category: Klontz EH]]
-[[Category: Sundberg, E J]]
+[[Category: Orwenyo J]]
-[[Category: Trastoy, B]]
+[[Category: Sundberg EJ]]
-[[Category: Wang, L X]]
+[[Category: Trastoy B]]
-[[Category: Endo-beta-n-acetylglucosaminidase s2]]
+[[Category: Wang LX]]
-[[Category: Endoglycosidase s2]]
-[[Category: Endos2]]
-[[Category: Glycoside hydrolase]]
-[[Category: Hydrolase]]