6o3b: Difference between revisions

<table><tr><td colspan='2'>[[6o3b]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O3B FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3b OCA], [http://pdbe.org/6o3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o3b RCSB], [http://www.ebi.ac.uk/pdbsum/6o3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3b ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  

[[Category: Beilschmidt, M]]

[[Category: Fransson, J]]

[[Category: Julien, J P]]

[[Category: Raman, S]]

[[Category: Wnt]]