6obx: Difference between revisions

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-'''Unreleased structure'''
-The entry 6obx is ON HOLD
+==Montbretin A analogue M10-MbA in complex with Human pancreatic alpha-amylase==
+<StructureSection load='6obx' size='340' side='right'caption='[[6obx]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6obx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OBX FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=ZXU:(2~{S})-~{N}-[3-[2-[3,4-bis(oxidanyl)phenyl]-5,7-bis(oxidanyl)-4-oxidanylidene-chromen-3-yl]oxypropyl]-2-[[(~{E})-3-[3,4-bis(oxidanyl)phenyl]prop-2-enoyl]amino]-3-(4-hydroxyphenyl)propanamide'>ZXU</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6obx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6obx OCA], [https://pdbe.org/6obx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6obx RCSB], [https://www.ebi.ac.uk/pdbsum/6obx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6obx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AMYP_HUMAN AMYP_HUMAN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, K I = 60 and 70 nM, with improved specificity over medically relevant glycosidases, making them promising candidates for controlling blood glucose. Crystallographic analysis confirmed similar binding modes and identified new active site interactions.
-Authors: Caner, S., Brayer, G.D.
+Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic alpha-amylase.,Tysoe CR, Caner S, Calvert MB, Win-Mason A, Brayer GD, Withers SG Chem Sci. 2019 Oct 18;10(48):11073-11077. doi: 10.1039/c9sc02610j. eCollection, 2019 Dec 28. PMID:32206255<ref>PMID:32206255</ref>
-Description: Montbretin A analogue M10-MbA in complex with Human pancreatic alpha-amylase
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Brayer, G.D]]
+<div class="pdbe-citations 6obx" style="background-color:#fffaf0;"></div>
-[[Category: Caner, S]]
+==See Also==
+*[[Amylase 3D structures|Amylase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Brayer GD]]
+[[Category: Caner S]]