Aspartate carbamoyltransferase: Difference between revisions

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</StructureSection>
</StructureSection>
==3D structures of aspartate carbamoyltransferase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*ATC
**[[2atc]], [[3at1]], [[6at1]], [[1pg5]], [[3d7s]], [[4wto]] – EcATC C+R subunits  – ''Escherichia coli''<br />
**[[9atc]]  – EcATC C (mutant) + R (mutant) subunits  <br />
**[[1ezz]], [[4e2f]] – EcATC C (mutant) + R subunits  <br />
**[[2qg9]], [[2qgf]]  – EcATC C + R (mutant) subunits  <br />
**[[3csu]] – EcATC C  <br />
**[[5vmq]], [[3npm]] – EcATC C (mutant)  <br />
**[[2be7]]  – ATC C (mutant) + R subunits – ''Moritella profunda'' <br />
**[[2at2]], [[3r7d]], [[3r7f]] – BsATC – ''Bacillus subtilis''<br />
**[[2rgw]], [[3e2p]], [[4ekn]] – MjATC C subunit – ''Methanocaldococcus jannaschii''<br />
**[[3lxm]] – ATC C subunit – ''Yersinia pestis''<br />
**[[5ilq]], [[5iln]] – ATC – ''Plasmodium falciparum''<br />
*ATC binary complex
**[[1at1]]  – EcATC C+R subunits  + malonate<br />
**[[1sku]]  – EcATC C (mutant) +R subunits  + malonate<br />
**[[1r0b]]  – EcATC C+R subunits  + citrate<br />
**[[1r0c]]  – EcATC C+R subunits  + N-carbamoyl-L-aspartate + phosphate<br />
**[[1xjw]]  – EcATC C (mutant) +R subunits  + PALA <br />
**[[1sku]]  – EcATC C (mutant) +R subunits  + phosphonoacetamide<br />
**[[1tu0]]  – EcATC C+R subunits  + maltose<br />
**[[4at1]]  – EcATC C+R subunits  + ATP<br />
**[[5at1]], [[1raa]], [[1rab]], [[1rac]], [[1rad]], [[1rae]], [[1raf]], [[1rag]], [[1rah]], [[1rai]], [[1za1]], [[4fyw]] – EcATC C+R subunits  + CTP<br />
**[[8atc]], [[1acm]], [[1d09]], [[1q95]] – EcATC C+R subunits  + PALA<br />
**[[1f1b]], [[1i5o]], [[1tth]]  – EcATC C (mutant) +R subunits  + PALA<br />
**[[2h3e]], [[2ipo]] – EcATC C+R subunits  + phosphonacetyl asparagine<br />
**[[1nbe]]  – EcATC C (mutant) + R (mutant) subunits  + malate<br />
**[[2a0f]]  – EcATC C (mutant) +R subunits + phosphonoacetamide<br />
**[[3mpu]]  – EcATC C (mutant) +R subunits + phosphate<br />
**[[1ekx]]  – EcATC C + bisubstrate analog<br />
**[[1ml4]]  – ATC C + bisubstrate analog – ''Pyrococcus abyssi''<br />
**[[2be9]] – ATC C+R subunits  + CTP – ''Sulfolobus acidocaldarius''<br />
**[[2yww]] – MjATC R subunit + ATP <br />
**[[3d6n]]  – AaATC +  dihydroorotase – ''Aqiufex aeolicus''<br />
**[[3r7l]]  – BsATC  + PALA<br />
*ATC ternary complex
**[[7at1]]  – EcATC C+R subunits  + ATP + maltose<br />
**[[8at1]]  – EcATC C+R subunits  + CTP + maltose<br />
**[[4fyv]]  – EcATC C+R subunits  + dCTP + phosphate<br />
**[[4fyx]]  – EcATC C+R subunits  + dCTP + UTP<br />
**[[4fyy]]  – EcATC C+R subunits  + CTP + UTP<br />
**[[1za2]]  – EcATC C+R subunits  + CTP + phosphoric monoformamide ester<br />
**[[2air]]  – EcATC C+R subunits  + L-alanosine + phosphoric monoformamide ester<br />
**[[2fzc]], [[2fzg]] – EcATC C+R subunits  + CTP + phosphonic acid derivative<br />
**[[2fzk]] – EcATC C+R subunits + CTP + phosphonacetyl benzoate<br />
**[[4f04]], [[4kgv]], [[4kgx]], [[4kgz]], [[4kh0]] – EcATC C+R subunits + nucleotide + PALA<br />
**[[2h3e]] – EcATC C+R subunits  + phosphonacetyl asparagine + malate<br />
**[[2at1]] – EcATC C+R subunits  + phosphonacetamide + malate<br />
**[[2hse]] – EcATC C+R subunits  + phosphonacetamide + aspartate<br />
**[[3d6n]], [[4bjh]]  – AaATC +  dihydroorotase + PALA <br />
*ATC quaternary complex
**[[1tug]]  – EcATC C (mutant) +R subunits + phosphate + aspartate + phosphonoacetamide<br />
**[[1tug]]  – EcATC C (mutant) +R subunits + CTP + malonate + phosphonoacetamide<br />
**[[4kh1]] – EcATC C+R subunits + UTP + CTP + phosphate + phosphonacetyl aspartate<br />
}}


== References ==
== References ==

Latest revision as of 14:16, 21 March 2019

Function

Aspartate carbamoyltransferase (ATC) is part of the pyrimidine biosynthesis pathway. ATC catalyzes the condensation of aspartate and carbamoyl phosphate to N-carbamyl-L-aspartate and phosphate. The Zn atom is essential for the association of the subunits. Binding of the substrate to the catalytic subunits results in a high-affinity state while binding of CTP to the regulatory subunit results in a low-affinity state. Malate and phosphonoacetyl-L-aspartate (PALA) are inhibitors of ATC. For additional details see Aspartate Transcarbamoylase (ATCase).

Structural highlights

ATC is composed of . Click to see and . The contains an and a carbamoyl-phosphate-binding domain. The regulatory subunit contains a nucleotide effectors-binding domain and a zinc domain. [1]

3D structures of aspartate carbamoyltransferase

Aspartate carbamoyltransferase 3D structures


Structure of E. coli aspartate carbamoyltransferase catalytic (cyan and pink) and regulatory (green and yellow) subunits complex with inhibitor PALA and Zn+2 ions (grey) (PDB code 1d09).

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Jin L, Stec B, Lipscomb WN, Kantrowitz ER. Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1 A. Proteins. 1999 Dec 1;37(4):729-42. PMID:10651286

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Michal Harel, Alexander Berchansky, Joel L. Sussman
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