4cv8: Difference between revisions

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<StructureSection load='4cv8' size='340' side='right'caption='[[4cv8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4cv8' size='340' side='right'caption='[[4cv8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cv8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CV8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CV8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3D7:3-AMINO-5-(1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3D7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cv9|4cv9]], [[4cva|4cva]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D7:3-AMINO-5-(1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3D7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [https://pdbe.org/4cv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4cv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cv8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [http://pdbe.org/4cv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4cv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cv8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  
 
==See Also==
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bavetsias, V]]
[[Category: Bavetsias V]]
[[Category: Bayliss, R]]
[[Category: Bayliss R]]
[[Category: Fearon, D]]
[[Category: Fearon D]]
[[Category: Jones, K]]
[[Category: Jones K]]
[[Category: Schmitt, J]]
[[Category: Schmitt J]]
[[Category: Westwood, I M]]
[[Category: Westwood IM]]
[[Category: VanMontfort, R L.M]]
[[Category: VanMontfort RLM]]
[[Category: Inhibitor]]
[[Category: Transferase]]

Latest revision as of 15:16, 20 December 2023

MPS1 kinase with 3-aminopyridin-2-one inhibitorsMPS1 kinase with 3-aminopyridin-2-one inhibitors

Structural highlights

4cv8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TTK_HUMAN Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]

See Also

References

  1. ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046

4cv8, resolution 3.00Å

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