4c4j: Difference between revisions

<table><tr><td colspan='2'>[[4c4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C4J FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=X21:TERT-BUTYL+6-{[2-CHLORO-4-(1-METHYL-1H-IMIDAZOL-5-YL)PHENYL]AMINO}-2-(1-METHYL-1H-PYRAZOL-4-YL)-1H-PYRROLO[3,2-C]PYRIDINE-1-CARBOXYLATE'>X21</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c4j OCA], [https://pdbe.org/4c4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c4j RCSB], [https://www.ebi.ac.uk/pdbsum/4c4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c4j ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  

*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Atrash B]]

[[Category: Baker R]]

[[Category: Bavetsias V]]

[[Category: Blagg J]]

[[Category: Boxall K]]

[[Category: Burke R]]

[[Category: Choi V]]

[[Category: Eccles SA]]

[[Category: Faisal A]]

[[Category: Gurden M]]

[[Category: Hayes A]]

[[Category: Henley A]]

[[Category: Linardopoulos S]]

[[Category: Liu M]]

[[Category: Mak G]]

[[Category: Matijssen B]]

[[Category: McAndrew C]]

[[Category: Naud S]]

[[Category: Raynaud FI]]

[[Category: Schmitt J]]

[[Category: Sheldrake P]]

[[Category: Valenti M]]

[[Category: Westwood IM]]

[[Category: Wood A]]

[[Category: De Haven Brandon A]]

[[Category: Van Montfort R]]