4ar8: Difference between revisions

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 <StructureSection load='4ar8' size='340' side='right'caption='[[4ar8]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ar8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AR8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ar8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AR8 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IP8:ISOPENTENYL+PHOSPHATE'>IP8</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IP8:ISOPENTENYL+PHOSPHATE'>IP8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ar9|4ar9]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ar8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ar8 OCA], [https://pdbe.org/4ar8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ar8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ar8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ar8 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ar8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ar8 OCA], [http://pdbe.org/4ar8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ar8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ar8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ar8 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/COLT_CLOTE COLT_CLOTE] Clostridial collagenases are among the most efficient degraders of eukaryotic collagen known; saprophytes use collagen as a carbon source while pathogens additionally digest collagen to aid in host colonization. Has both tripeptidylcarboxypeptidase on Gly-X-Y and endopeptidase activities; the endopeptidase cuts within the triple helix region of collagen while tripeptidylcarboxypeptidase successively digests the exposed ends, thus clostridial collagenases can digest large sections of collagen (By similarity). The activator domain (residues 57-330) and catalytic subdomain (340-611) open and close around substrate allowing digestion when the protein is closed (PubMed:23703618).[UniProtKB:Q9X721]<ref>PMID:18937627</ref> <ref>PMID:23703618</ref> <ref>PMID:24125730</ref> <ref>PMID:28820255</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 ==See Also==
-*[[Collagenase (non-MMP)|Collagenase (non-MMP)]]
+*[[Collagenase 3D structures|Collagenase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Bacillus tetani flugge 1886]]
+[[Category: Clostridium tetani]]
-[[Category: Brandstetter, H]]
+[[Category: Large Structures]]
-[[Category: Eckhard, U]]
+[[Category: Synthetic construct]]
-[[Category: Collagenolysis]]
+[[Category: Brandstetter H]]
-[[Category: Hydrolase]]
+[[Category: Eckhard U]]
-[[Category: Hydrolase-inhibitor complex]]
-[[Category: Metalloprotease]]
-[[Category: Peptidase]]