4ayo: Difference between revisions

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<StructureSection load='4ayo' size='340' side='right'caption='[[4ayo]], [[Resolution|resolution]] 0.85&Aring;' scene=''>
<StructureSection load='4ayo' size='340' side='right'caption='[[4ayo]], [[Resolution|resolution]] 0.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ayo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Causk Causk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYO FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ayo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_sp._K31 Caulobacter sp. K31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ayp|4ayp]], [[4ayq|4ayq]], [[4ayr|4ayr]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayo OCA], [https://pdbe.org/4ayo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayo RCSB], [https://www.ebi.ac.uk/pdbsum/4ayo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayo OCA], [http://pdbe.org/4ayo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ayo RCSB], [http://www.ebi.ac.uk/pdbsum/4ayo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B0SWV2_CAUSK B0SWV2_CAUSK]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Mannosidase|Mannosidase]]
*[[Mannosidase 3D structures|Mannosidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Causk]]
[[Category: Caulobacter sp. K31]]
[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]
[[Category: Large Structures]]
[[Category: Dabin, J]]
[[Category: Dabin J]]
[[Category: Davies, G J]]
[[Category: Davies GJ]]
[[Category: Dinev, Z]]
[[Category: Dinev Z]]
[[Category: Gilbert, H J]]
[[Category: Gilbert HJ]]
[[Category: Hu, T C]]
[[Category: Hu TC]]
[[Category: Iglesias-Fernandez, A]]
[[Category: Iglesias-Fernandez A]]
[[Category: Iglesias-Fernandez, J]]
[[Category: Iglesias-Fernandez J]]
[[Category: Moreland, C]]
[[Category: Moreland C]]
[[Category: Rovira, C]]
[[Category: Rovira C]]
[[Category: Siriwardena, A]]
[[Category: Siriwardena A]]
[[Category: Smith, D K]]
[[Category: Smith DK]]
[[Category: Thompson, A J]]
[[Category: Thompson AJ]]
[[Category: Williams, S J]]
[[Category: Williams SJ]]
[[Category: Alpha-mannosidase]]
[[Category: Cazy]]
[[Category: Enzyme-carbohydrate interaction glycosidase inhibition]]
[[Category: Gh47]]
[[Category: Glycoside hydrolase]]
[[Category: Hydrolase]]

Latest revision as of 14:38, 20 December 2023

Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31

Structural highlights

4ayo is a 1 chain structure with sequence from Caulobacter sp. K31. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 0.85Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

B0SWV2_CAUSK

Publication Abstract from PubMed

Mannosides in the southern hemisphere: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhibition and inspires solutions to mannoside synthesis. Atomic resolution structures along the reaction coordinate of an inverting alpha-mannosidase show how the enzyme distorts the substrate and transition state. QM/MM calculations reveal how the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conformationally accessible reaction coordinate.

The reaction coordinate of a bacterial GH47 alpha-mannosidase: a combined quantum mechanical and structural approach.,Thompson AJ, Dabin J, Iglesias-Fernandez J, Ardevol A, Dinev Z, Williams SJ, Bande O, Siriwardena A, Moreland C, Hu TC, Smith DK, Gilbert HJ, Rovira C, Davies GJ Angew Chem Int Ed Engl. 2012 Oct 29;51(44):10997-1001. doi:, 10.1002/anie.201205338. Epub 2012 Sep 26. PMID:23012075[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Thompson AJ, Dabin J, Iglesias-Fernandez J, Ardevol A, Dinev Z, Williams SJ, Bande O, Siriwardena A, Moreland C, Hu TC, Smith DK, Gilbert HJ, Rovira C, Davies GJ. The reaction coordinate of a bacterial GH47 alpha-mannosidase: a combined quantum mechanical and structural approach. Angew Chem Int Ed Engl. 2012 Oct 29;51(44):10997-1001. doi:, 10.1002/anie.201205338. Epub 2012 Sep 26. PMID:23012075 doi:http://dx.doi.org/10.1002/anie.201205338

4ayo, resolution 0.85Å

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