2wwp: Difference between revisions
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==Crystal structure of the human lipocalin-type prostaglandin D synthase== | ==Crystal structure of the human lipocalin-type prostaglandin D synthase== | ||
<StructureSection load='2wwp' size='340' side='right' caption='[[2wwp]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2wwp' size='340' side='right'caption='[[2wwp]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wwp]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wwp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwp OCA], [https://pdbe.org/2wwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wwp RCSB], [https://www.ebi.ac.uk/pdbsum/2wwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wwp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Berglund H]] | |||
[[Category: Berglund | [[Category: Bountra C]] | ||
[[Category: Bountra | [[Category: Collins R]] | ||
[[Category: Collins | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: Flodin S]] | ||
[[Category: Flodin | [[Category: Flores A]] | ||
[[Category: Flores | [[Category: Graslund S]] | ||
[[Category: Graslund | [[Category: Hammarstrom M]] | ||
[[Category: Hammarstrom | [[Category: Johansson A]] | ||
[[Category: Johansson | [[Category: Johansson I]] | ||
[[Category: Johansson | [[Category: Kallas A]] | ||
[[Category: Kallas | [[Category: Karlberg T]] | ||
[[Category: Karlberg | [[Category: Kotyenova T]] | ||
[[Category: Kotyenova | [[Category: Kotzch A]] | ||
[[Category: Kotzch | [[Category: Kraulis P]] | ||
[[Category: Kraulis | [[Category: Markova N]] | ||
[[Category: Markova | [[Category: Moche M]] | ||
[[Category: Moche | [[Category: Nielsen TK]] | ||
[[Category: Nielsen | [[Category: Nordlund P]] | ||
[[Category: Nordlund | [[Category: Nyman T]] | ||
[[Category: Nyman | [[Category: Persson C]] | ||
[[Category: Persson | [[Category: Roos AK]] | ||
[[Category: Roos | [[Category: Schuler H]] | ||
[[Category: Schutz P]] | |||
[[Category: Schuler | [[Category: Siponen MI]] | ||
[[Category: Schutz | [[Category: Svensson L]] | ||
[[Category: Siponen | [[Category: Thorsell AG]] | ||
[[Category: Svensson | [[Category: Tresaugues L]] | ||
[[Category: Thorsell | [[Category: Van Den Berg S]] | ||
[[Category: Tresaugues | [[Category: Wahlberg E]] | ||
[[Category: Wahlberg | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Welin M]] | ||
[[Category: Welin | [[Category: Wisniewska M]] | ||
[[Category: Wisniewska | |||