6o0h: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 6o0h is ON HOLD
+==Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143==
+<SX load='6o0h' size='340' side='right' viewer='molstar' caption='[[6o0h]], [[Resolution|resolution]] 3.67&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6o0h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O0H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.67&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=LBG:methyl+3-chloro-5-[(4,6-difluoro[1,1-biphenyl]-3-yl)sulfamoyl]-4-hydroxybenzoate'>LBG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o0h OCA], [https://pdbe.org/6o0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o0h RCSB], [https://www.ebi.ac.uk/pdbsum/6o0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o0h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref>
-Authors:
+==See Also==
+*[[ATP-citrate synthase 3D structures|ATP-citrate synthase 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</SX>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Tong L]]
+[[Category: Wei J]]