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| == Function == | | == Function == |
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| '''CREB-binding protein''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref> | | '''CREB-binding protein''' or '''CREBBP''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref> |
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| == Disease == | | == Disease == |
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| <scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref> | | <scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref> |
| </StructureSection>
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| == 3D Structures of CREB-binding protein == | | == 3D Structures of CREB-binding protein == |
| | [[CREB-binding protein 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *CBP
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| **[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />
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| **[[1f81]] – mCBP TAZ2 domain - NMR <br />
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| **[[1u2n]] – mCBP TAZ1 domain - NMR <br />
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| **[[1jjs]] – mCBP IBiD domain - NMR<br />
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| **[[1liq]] – mCBP CH1 domain - NMR<br />
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| **[[1tot]] – mCBP ZZ domain – NMR <br />
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| **[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
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| **[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
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| **[[2d82]] – hCBP bromodomain - NMR<br />
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| **[[3dwy]], [[4ouf]], [[4whu]] – hCBP bromodomain <br />
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| **[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]], [[4tqn]], [[4ts8]], [[4yk0]], [[5cgp]], [[5dbm]], [[5eic]], [[5eng]], [[5ep7]], [[5h85]], [[5i83]], [[5i86]], [[5i89]], [[5i8b]], [[5i8g]], [[5j0d]], [[5ktu]], [[5ktw]], [[5ktx]], [[5tb6]] – hCBP bromodomain + inhibitor<br />
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| **[[2l84]], [[2l85]] – hCBP bromodomain + inhibitor - NMR<br />
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| *CBP complex with protein
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| **[[1kbh]] – hCBP + nuclear receptor coactivator - NMR <br />
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| **[[1zoq]] – hCBP + interferon regulatory factor 3 <br />
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| **[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR<br />
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| **[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />
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| **[[1l8c]] – mCBP TAZ1 domain + hypoxia-inducible factor 1α - NMR<br />
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| **[[2lww]] - mCBP TAZ1 domain + nuclear transcription factor RELA – NMR <br />
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| **[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />
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| **[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />
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| **[[2n1a]] – hCBP + small ubiquitin-related modifier - NMR<br />
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| **[[5jem]] – hCBP residues 2065-2111 + interferon-3<br />
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| **[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
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| **[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />
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| **[[1jsp]] – hCBP bromodomain + p53 peptide - NMR<br />
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| **[[2l14]] – mCBP nuclear coactivator binding domain + p53 peptide - NMR<br />
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| **[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
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| **[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
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| **[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
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| **[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
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| **[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />
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| **[[2rny]] – hCBP bromodomain + histone H3 peptide - NMR<br />
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| **[[4n3w]], [[4n4f]] - hCBP bromodomain + histone H4 peptide <br />
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| **[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |