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==Structure of Dot1L-H2BK120ub nucleosome complex==
==Structure of Dot1L-H2BK120ub nucleosome complex==
<StructureSection load='6nn6' size='340' side='right' caption='[[6nn6]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
<SX load='6nn6' size='340' side='right' viewer='molstar' caption='[[6nn6]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6nn6]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NN6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6nn6]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NN6 FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nn6 OCA], [http://pdbe.org/6nn6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nn6 RCSB], [http://www.ebi.ac.uk/pdbsum/6nn6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nn6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nn6 OCA], [https://pdbe.org/6nn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nn6 RCSB], [https://www.ebi.ac.uk/pdbsum/6nn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nn6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
==See Also==
*[[Histone 3D structures|Histone 3D structures]]
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Anderson, C J]]
[[Category: Large Structures]]
[[Category: Baird, M R]]
[[Category: Synthetic construct]]
[[Category: Barbour, E H]]
[[Category: Xenopus laevis]]
[[Category: Borgnia, M J]]
[[Category: Anderson CJ]]
[[Category: Hsu, A]]
[[Category: Baird MR]]
[[Category: Koyama, Y]]
[[Category: Barbour EH]]
[[Category: McGinty, R K]]
[[Category: Borgnia MJ]]
[[Category: Chromatin]]
[[Category: Hsu A]]
[[Category: Cryo-em]]
[[Category: Koyama Y]]
[[Category: Dot1l]]
[[Category: McGinty RK]]
[[Category: Gene regulation]]
[[Category: Histone methyltransferase]]
[[Category: Nucleosome]]
[[Category: Single particle]]
[[Category: Structural biology]]

Latest revision as of 12:21, 20 March 2024

Structure of Dot1L-H2BK120ub nucleosome complexStructure of Dot1L-H2BK120ub nucleosome complex

6nn6, resolution 3.90Å

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