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[[Image:2a64.gif|left|200px]]


{{Structure
==Crystal Structure of Bacterial Ribonuclease P RNA==
|PDB= 2a64 |SIZE=350|CAPTION= <scene name='initialview01'>2a64</scene>, resolution 3.300&Aring;
<StructureSection load='2a64' size='340' side='right'caption='[[2a64]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
<table><tr><td colspan='2'>[[2a64]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A64 FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a64 OCA], [https://pdbe.org/2a64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a64 RCSB], [https://www.ebi.ac.uk/pdbsum/2a64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a64 ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a64 OCA], [http://www.ebi.ac.uk/pdbsum/2a64 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a64 RCSB]</span>
}}


'''Crystal Structure of Bacterial Ribonuclease P RNA'''
==See Also==
 
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The x-ray crystal structure of a 417-nt ribonuclease P RNA from Bacillus stearothermophilus was solved to 3.3-A resolution. This RNA enzyme is constructed from a number of coaxially stacked helical domains joined together by local and long-range interactions. These helical domains are arranged to form a remarkably flat surface, which is implicated by a wealth of biochemical data in the binding and cleavage of the precursors of transfer RNA substrate. Previous photoaffinity crosslinking data are used to position the substrate on the crystal structure and to identify the chemically active site of the ribozyme. This site is located in a highly conserved core structure formed by intricately interlaced long-range interactions between interhelical sequences.
[[Category: Geobacillus stearothermophilus]]
 
[[Category: Large Structures]]
==About this Structure==
[[Category: Adams PD]]
2A64 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A64 OCA].
[[Category: Harrington DJ]]
 
[[Category: Holbrook SR]]
==Reference==
[[Category: Kazantsev AV]]
Crystal structure of a bacterial ribonuclease P RNA., Kazantsev AV, Krivenko AA, Harrington DJ, Holbrook SR, Adams PD, Pace NR, Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13392-7. Epub 2005 Sep 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16157868 16157868]
[[Category: Krivenko AA]]
[[Category: Single protein]]
[[Category: Pace NR]]
[[Category: Adams, P D.]]
[[Category: Harrington, D J.]]
[[Category: Holbrook, S R.]]
[[Category: Kazantsev, A V.]]
[[Category: Krivenko, A A.]]
[[Category: Pace, N R.]]
[[Category: hydrolase]]
[[Category: ribonuclease]]
[[Category: ribozyme]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Apr  1 09:01:25 2008''

Latest revision as of 12:11, 14 February 2024

Crystal Structure of Bacterial Ribonuclease P RNACrystal Structure of Bacterial Ribonuclease P RNA

Structural highlights

2a64 is a 1 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

2a64, resolution 3.30Å

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