Ferredoxin NADP+ Reductase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Rebecca Truitt, Dana Emmert, Michal Harel, Jaime Prilusky, Alexander Berchansky

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 <StructureSection load='4FK8' size='340' frame='true' side='right' caption='FNR protein containg FAD (PDB code [[4fk8]])' scene=''>
+==Function==
 '''Ferredoxin NADP<sup>+</sup> reductase''' [http://en.wikipedia.org/wiki/Ferredoxin—NADP(%2B)_reductase] is an enzyme that catalyzes the reduction of NADP<sup>+</sup> to NADPH.  This enzyme belongs to a family of enzymes called oxidoreductases[http://en.wikipedia.org/wiki/Oxidoreductase] that contain iron-sulfur proteins as electron donors and NAD<sup>+</sup> or NADP<sup>+</sup> as electron acceptors. FAD, [flavin adenine dinucleotide][http://en.wikipedia.org/wiki/Flavin_adenine_dinucleotide], is also a cofactor of FNR. The ferredoxin NADP<sup>+</sup> reductase participates in a general reaction that proceeds as follows:
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 ==Other Functions==
-FNR is also an active protein in plants, and is found in the chloroplast and thylakoid membrane of the cell. The FNR reductive mechanism is responsible for the transfer of the final electrons during photosynthesis from photosystem I to NADPH, which then goes on to participate the Calvin cycle as a reducing cofactor.
+FNR is also an active protein in plants, and is found in the chloroplast and thylakoid membrane of the cell. The FNR reductive mechanism is responsible for the transfer of the final electrons during photosynthesis from photosystem I to NADPH, which then goes on to participate the [[Calvin cycle]] as a reducing cofactor.
 In other organisms, FNR plays a role in metabolism such as oxidative stress response and steroid metabolism.[http://en.wikipedia.org/wiki/Ferredoxin—NADP(%2B)_reductase]
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 == 3D Structures of Ferredoxin NADP+ reductase ==
+[[Ferredoxin NADP+ Reductase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*FNR
-**[[3lxd]] – FNR ARR – ''Novosphingobium aromaticivorans''<br />
-**[[2x3u]], [[2bmw]], [[1w34]], [[1w35]], [[1h42]], [[1gr1]], [[1h85]], [[4bpr]], [[4c43]] – AnFNR (mutant) – Anabena<br />
-**[[1ogi]], [[1ogj]] - AnFNR fragment (mutant)<br />
-**[[2vyq]], [[1go2]], [[3zbt]], [[3zbu]] - NoFNR fragment (mutant) – Nostoc<br />
-**[[1qgy]], [[1bqe]], [[1qgz]], [[1qh0]], [[1e62]], [[1e63]], [[1e64]], [[1b2r]], [[1bjk]] - NoFNR (mutant)<br />
-**[[1que]] - NoFNR<br />
-**[[3fpk]] - FNR – ''Salmonela typhimurium''<br />
-**[[2bgj]] - RcFNR (mutant)<br />
-**[[2qdx]] - PaFNR – ''Pseudomonas aeruginosa''<br />
-**[[2gqw]], [[2gr0]], [[2gr1]], [[1d7y]] – PsFNR - ''Pseudomonas sp.''<br />
-**[[2gr3]] – PsFNR (mutant)<br />
-**[[2rc5]] - LiFNR – ''Leptospira interrogans''<br />
-**[[2b5o]] - FNR – ''Synechococcus sp.''<br />
-**[[1sm4]] - FNR – paprika<br />
-**[[1a8p]] - FNR – ''Azotobacter vinelandii''<br />
-**[[1fdr]] - EcFNR (mutant) – ''Escherichia coli''<br />
-**[[1frn]], [[1fnb]] - spFNR – spinach<br />
-**[[1bx0]], [[1bx1]], [[1frq]] – spFNR (mutant)<br />
-**[[2xnc]], [[1qg0]] – pFNR - pea<br />
-**[[4af6]], [[4af7]] – pFNR (mutant) <br />
-**[[3ab1]] – FNR – ''Chlorobaculum tepidum''<br />
-**[[4f7d]] – BtFNR no FAD – ''Burkholderia thailandensis''<br />
-**[[4fk8]] - BtFNR <br />
-**[[3jqr]] - PfFNR (mutant) – ''Plasmodium falciparum''<br />
-**[[4b4d]] – FNR – ''Xanthomonas axonopodis''<br />
-*FNR+NADP
-**[[1gjr]], [[1w87]] - AnFNR fragment+NADP<br />
-**[[2bsa]] - AnFNR (mutant)+NADP<br />
-**[[2vzl]], [[1quf]], [[3zc3]] - NoFNR fragment (mutant)+NAD<br />
-**[[2vnh]] - RcFNR+NADP – ''Rhodobacter capsulatus''<br />
-**[[3crz]] - PaFNR  + NADP<br />
-**[[2rc6]] - LiFNR+NADP<br />
-**[[1qfy]], [[1qfz]], [[1qga]] - pFNR (mutant)+NADP <br />
-**[[2vnj]], [[2vnk]] - RcFNR+NADP<br />
-**[[2xnj]] - EcFNR+NADP<br />
-**[[1lqu]] - MtFNR+NADP - ''Mycobacterium tuberculosis''<br />
-**[[1f3p]] – PsFNR  + NADP<br />
-**[[3lzw]], [[3lzx]] – FNR 2 + NADP – ''Bacillus subtilis''<br />
-**[[5thx]] - NgFNR  + NADP + FAD – ''Neisseria gonorrhoeae''<br />
-**[[5vw2]], [[5vw3]], [[5vw6]], [[5vw7]], [[5vw8]], [[5vwb]] - mFNR  (mutant) + NADP + FAD derivative - maize<br />
-*FNR+Fd
-**[[1gaq]] - mFNR+ FAD + Fd-1 - maize<br />
-**[[5h5j]] - mFNR  + FAD + Fd-3<br />
-**[[1ewy]] - NoFNR fragment + Fd<br />
-**[[3jqp]], [[3jqr]] - FNR (mutant)+2P-AMP – ''Plasmodium falciparum''<br />
-*FNR other complexes
-**[[2vni]] - RcFNR+A2P<br />
-**[[2bgi]] - RcFNR (mutant)+detergent<br />
-**[[2yvj]], [[2yvf]], [[2yvg]] - pFNR+ NAD + biphenyl dioxygenase Fd subunit<br />
-**[[3jqq]] – PfFNR + A2P<br />
-**[[3mhp]] – pFNR + peptide<br />
-**[[3jqp]] - FNR (mutant)+A2P<br />
-**[[2gr0]], [[2gr2]] – SpFNR  + ADP derivative<br />
-**[[2c7g]] - MtFNR (mutant)  + ODP – ''Mycobacterium tuberculosis''<br />
-**[[1lqt]] - MtFNR  + ODP<br />
-**[[1fnc]], [[1fnd]] – spFNR  + A2P<br />
-**[[5tr9]] - NgFNR  + FAD <br />
-**[[3lo8]], [[3lvb]], [[1jb9]], [[1gaw]] – mFNR + FAD <br />
-**[[5vw4]], [[5vw5]], [[5vw9]] - mFNR  (mutant) + nicotinamide + FAD <br />
-**[[5zbv]], [[5twb]], [[5twc]] – FNR + FAD – ''Staphylococcus aureus''<br />
-**[[5xhu]] – BsFNR + FAD <br />
-**[[5h59]] - mFNR  + FAD <br />
-**[[5vwa]] - mFNR  (mutant) + FAD <br />
-**[[4k1x]] - RcFNR  (mutant) + FAD <br />
-**[[5vj7]] – FNR + oxidoreductase + FAD + Fe2S2 – ''Pyrococcus furiosus''<br />
-}}
 == References ==
 <references/>
+[[Category:Topic Page]]