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==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055==
==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055==
<StructureSection load='3jtk' size='340' side='right' caption='[[3jtk]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
<StructureSection load='3jtk' size='340' side='right'caption='[[3jtk]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3jtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JTK FirstGlance]. <br>
<table><tr><td colspan='2'>[[3jtk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JTK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=X55:(2R)-3-BENZYL-2-(2-BROMO-4-HYDROXY-5-METHOXYPHENYL)-1,3-THIAZOLIDIN-4-ONE'>X55</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iu1|3iu1]], [[3iu2|3iu2]], [[3iwe|3iwe]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=X55:(2R)-3-BENZYL-2-(2-BROMO-4-HYDROXY-5-METHOXYPHENYL)-1,3-THIAZOLIDIN-4-ONE'>X55</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMT, NMT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jtk OCA], [https://pdbe.org/3jtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jtk RCSB], [https://www.ebi.ac.uk/pdbsum/3jtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jtk ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jtk OCA], [http://pdbe.org/3jtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jtk RCSB], [http://www.ebi.ac.uk/pdbsum/3jtk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jtk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.  
[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Brand, S Y]]
[[Category: Brand SY]]
[[Category: Cossar, D]]
[[Category: Cossar D]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Ferguson, M A.J]]
[[Category: Ferguson MAJ]]
[[Category: Frearson, J A]]
[[Category: Frearson JA]]
[[Category: Hui, R]]
[[Category: Hui R]]
[[Category: Hutchinson, A]]
[[Category: Hutchinson A]]
[[Category: Kania, A]]
[[Category: Kania A]]
[[Category: Kozieradzki, I]]
[[Category: Kozieradzki I]]
[[Category: Lin, Y H]]
[[Category: Lin Y-H]]
[[Category: Qiu, W]]
[[Category: Qiu W]]
[[Category: Ravichandran, M]]
[[Category: Ravichandran M]]
[[Category: Robinson, D A]]
[[Category: Robinson DA]]
[[Category: Structural genomic]]
[[Category: Schapira M]]
[[Category: Schapira, M]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Wernimont A]]
[[Category: Wernimont, A]]
[[Category: Wyatt PG]]
[[Category: Wyatt, P G]]
[[Category: Acyltransferase]]
[[Category: N-myristoyltransferase]]
[[Category: Nmt1]]
[[Category: Phosphoprotein]]
[[Category: Sgc]]
[[Category: Transferase]]

Latest revision as of 11:03, 6 September 2023

Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055

Structural highlights

3jtk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.61Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NMT1_HUMAN Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3jtk, resolution 1.61Å

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OCA
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